Abstract
Previous studies have suggested that risk for malignant melanoma is elevated in users of phosphodiesterase type 5 (PDE5) inhibitors (sildenafil, vardenafil, tadalafil) for erectile dysfunction. A theoretical biologic mechanism exists: Downregulation of PDE5 is thought to increase invasiveness of melanoma. Researchers identified 4065 Swedish men with incident malignant melanoma and …
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