Abstract
ObjectiveThe association between enterovirus infection and type 1 diabetes (T1D) is controversial, and this meta-analysis aimed to explore the correlation.MethodsPubMed, Embase, Web of Science, and Cochrane Database were searched from inception to April 2020. Studies were included if they could provide sufficient information to calculate odds ratios and 95% confidence intervals. All analyses were performed using STATA 15.1.ResultsThirty-eight studies, encompassing 5921 subjects (2841 T1D patients and 3080 controls), were included. The pooled analysis showed that enterovirus infection was associated with T1D (P < 0.001). Enterovirus infection was correlated with T1D in the European (P < 0.001), African (P = 0.002), Asian (P = 0.001), Australian (P = 0.011), and Latin American (P = 0.002) populations, but no conclusion could be reached for North America. The association between enterovirus infection and T1D was detected in blood and tissue samples (both P < 0.001); no association was found in stool samples.ConclusionOur findings suggest that enterovirus infection is associated with T1D.
Highlights
Type 1 diabetes (T1D) is a multifactorial disease resulting from the autoimmune destruction or dysfunction of pancreatic b cells [1]
Enteroviruses can infect pancreatic b cells in pancreatic islets via the coxsackie and adenovirus receptor (CAR), which is expressed on b and a cells, and the viruses replicate in both these cell types [10, 11]
A previous meta-analysis was conducted to identify whether enterovirus infection was associated with T1D [17], the present meta-analysis consisted of the largest number of original
Summary
Type 1 diabetes (T1D) is a multifactorial disease resulting from the autoimmune destruction or dysfunction of pancreatic b cells [1]. Enterovirus genus belongs to the Picornaviridae family and consists of 15 species, seven of which contain human pathogens These human infecting enteroviruses are classified into four species (Enterovirus A-D and Rhinovirus A-C) and contain more than 250 serologically distinct viruses. Enteroviruses can infect pancreatic b cells in pancreatic islets via the CAR, which is expressed on b and a cells, and the viruses replicate in both these cell types [10, 11]. Both acute and persistent enterovirus infections have been shown to affect the functions of the host cell, inducing b cell death, decreasing insulin mRNA expression and insulin secretion, and disrupting the Golgi apparatus [11,12,13,14,15,16]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
