Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls

Jikang Shi,Lingfeng Pan,Yanbo Guo,Jiayi Xu,Siyu Liu,Yawen Liu,Sainan Liu,Yi Cheng,Yueyang Hu

doi:10.1186/s12872-021-02192-2

Jikang Shi, Lingfeng Pan + Show 7 more

Open Access

https://doi.org/10.1186/s12872-021-02192-2

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Abstract

BackgroundEssential hypertension is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension. Our study aimed to evaluate the association between eNOS rs1799983 polymorphism and hypertension, and to provide evidence for the etiology of hypertension.MethodsCase–control studies of eNOS rs1799983 polymorphism and hypertension were included by searching PubMed, Embase, Web of Science, Medline, Scopus, WanFang datebase, Vip datebase, and CNKI database according to PRISMA guideline. Eligible data were extracted and pooled, and were analyzed using R software based on five different genetic models.ResultsA total of 60 eligible articles involving 14,185 cases and 13,407 controls were finally selected. We found significant association between eNOS rs1799983 polymorphism and hypertension under any genetic model (T vs G: OR = 1.44, 95% CI 1.26–1.63; GT vs GG: OR 1.34, 95% CI 1.18–1.52; TT vs GG: OR 1.80, 95% CI 1.41–2.31; GT + TT vs GG: OR 1.42, 95% CI 1.25–1.63; TT vs GG + GT: OR 1.68, 95% CI 1.35–2.08; GT vs GG + TT: OR 1.24, 95% CI 1.11–1.40).ConclusionsWe found that eNOS rs1799983 polymorphism is associated with the increased risk of hypertension under any genetic model. Moreover, investigations of gene–gene and gene-environment interactions are needed to give more insight into the association between eNOS rs1799983 polymorphism and hypertension.

Highlights

Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors, Encoding endothelial nitric oxide synthase (eNOS) is considered to be one of the susceptible genes for hypertension
Inclusion/exclusion criteria Studies included had to meet the following criteria: (1) case–control studies; (2) patients with essential hypertension were defined as cases, healthy subjects without hypertension were defined as controls; (3) evaluation of the association between eNOS rs1799983 polymorphism and hypertension
Association between eNOS rs1799983 polymorphism and hypertension There were significant heterogeneities between eNOS rs1799983 polymorphism and hypertension in the five different genetic models, and random-effects model was used for all analyses

Summary

Introduction

Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension. There are about 10 polymorphic loci distributed in the promoter, exon, and intron of the eNOS gene In these loci, the common mutation that leads to amino acid substitutions in mature proteins is G894T or Glu298Asp (rs1799983) mutations, in which base substitution of G to T will result in glutamic acid (Glu) being replaced at exon 7 by aspartic acid (Asp) at position 298 of the corresponding amino acid [7]. The common mutation that leads to amino acid substitutions in mature proteins is G894T or Glu298Asp (rs1799983) mutations, in which base substitution of G to T will result in glutamic acid (Glu) being replaced at exon 7 by aspartic acid (Asp) at position 298 of the corresponding amino acid [7] This genetic mutation reduces the production of NO and subsequently affects the development of EH [8]

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