Abstract
The definition of sepsis has been updated as life-threatening organ dysfunction caused by a dysre-gulated host response to infection according to the Third International Consensus Definitions for Sepsis and Septic Shock (SEPSIS-3). Sepsis affects functions of endothelial cell (EC) which include vasoregulation, barrier function, infla-mmation, hemostasis, and is thought to be the key factor in the progression from sepsis to organ failure.Recent studies also demonstrated the mechanism of endothelial dysfunction in sepsis is mediated by glycocalyx shedding.This review covers the current insight in sepsis-associated endothelial dysfunction in different organ systems, as well as the clinical assessment and clinical trial aiming at the system of endothelium. Key words: Sepsis; Endothelium; Glycocalyx; Organ dysfunction
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