Association between Endoglin and nm23-H1 Expression and the Recurrence in Elderly Patients with Laryngeal Squamous Cell Carcinoma

Abstract

To explore the association between endoglin and nm23-H1 expression and the recurrence in elderly patients with laryngeal squamous cell carcinoma. Patients diagnosed with laryngeal squamous cell carcinoma in The First Affiliated Hospital of Soochow University Suzhou from January 2012 to April 2015 were selected as the subjects, all patients underwent surgical resection and followed up for 5 y, and disease recurrence was chosen as the experimental endpoint. The basic clinical data of all patients were collected, immunohistochemical methods was used to evaluate the expression of endoglin and nm23-H1. According to disease recurrence patients were divided into relapse group and non-relapse group, the differences between the two groups were compared. The independent related factors affecting the relapse of patients were investigated by Logistic regression analysis. 32 patients relapsed with a recurrence rate of 31.37 %. There were significant differences in T stage, clinical stage, and pathological grade between the two groups. The positive expression rate of endoglin in the relapse group was significantly higher than that in the non-relapse group ((6.51±0.64) % vs. (5.63±0.57) %, p<0.001); the positive expression rate of nm23-H1 was significantly lower than that in the non-relapse group ((9.71±0.84) % vs. (10.52±0.78) %). Multivariate logistic regression analysis showed that nm23-H1 and endoglin were independent related factors that affected the recurrence of the disease. Endoglin expression ≥5.91%, nm23-H1 expression <10.27 % are independent risk factors that affect patients’ relapse.