Abstract
Purpose: Muscle co-activation is associated with knee osteoarthritis (OA) severity and quadriceps muscle weakness is a known risk factor for the development of symptomatic knee OA as well as worsening of joint space narrowing. Our prior work demonstrated that net quadriceps strength is attenuated by hamstring coactivation in women but not men and that, in men, greater hamstring coactivation is associated with elevated risk of cartilage loss. One potential explanation for why greater coactivation is associated with cartilage loss in men but not in women relates to the potential for higher forces across the knee joint in the presence of both higher strength and coactivation.
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