Abstract
BackgroundTo estimate the prevalence of elevated blood glucose level (EBG, including type 2 diabetes mellitus and impaired fasting glucose), and its association with non-valvular atrial fibrillation (NVAF) in Guangzhou, China.MethodsThe population-based follow-up Guangzhou Heart Study collected baseline data from July 2015 to August 2017 among 12,013 permanent residents aged > 35 from 4 Guangzhou districts. Two streets (Dadong and Baiyun) in the Yuexiu District, and one street (Xiaoguwei) and two towns (Xinzao and Nancun) in the Panyu District were chosen as representative of urban and rural areas, respectively. Each participant completed a comprehensive questionnaire, and underwent physical examination, blood sample collection for laboratory testing, electrocardiography, and other evaluations. Multivariable logistic regression analyses were used to estimate the independent association between hyperglycemia and NVAF prevalence.ResultsThe prevalence of EBG in overall study population was 29.9%. Compared with residents without EBG, the odds ratio (OR) for AF among residents with EBG was significantly higher (1.94, 95% confidence interval [CI]: 1.40–2.70, P < 0.001), even after multivariate adjustment for metabolic abnormalities (OR = 1.60, 95% CI: 1.14–2.25, P = 0.007), and driven by women (OR = 1.80, 95% CI: 1.12–2.91, P = 0.016).ConclusionsIn Guangzhou, China, prevalence of EBG is high among residents aged > 35 years and associated with a multivariate adjusted increase in prevalence of NVAF overall and in women.
Highlights
To estimate the prevalence of elevated blood glucose level (EBG, including type 2 diabetes mellitus and impaired fasting glucose), and its association with non-valvular atrial fibrillation (NVAF) in Guangzhou, China
Individuals with the following conditions were excluded: 1) mobility difficulties including high paraplegia; 2) mental or cognitive disorders including disturbance of understanding, dementia, and deaf-mutters; 3) pregnant or lactating females; 4) malignant tumors under treatment; 5) floating population including tenants; 6) Guangzhou residents not living in the selected communities for at least 6 months by the day they participated in the survey; 7) non-Guangzhou residents; and 8) non-responders during the 3-round mobilization
Among the 175 participants, 31 were diagnosed with valvular disease, the remaining 144 NVAF were entered into the final data analysis
Summary
To estimate the prevalence of elevated blood glucose level (EBG, including type 2 diabetes mellitus and impaired fasting glucose), and its association with non-valvular atrial fibrillation (NVAF) in Guangzhou, China. Atrial fibrillation (AF), one of the most common cardiac arrhythmias in the general population, is associated with increased risk of ischemic stroke/systemic embolism, heart failure, myocardial infarction and mortality from. Abnormal glucose metabolism, characterized by elevated blood glucose level (EBG), is one of the most common metabolic diseases, and mainly includes T2D and pre-diabetes status, i.e., impaired fasting glucose (IFG).
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