Abstract
肺癌是我国恶性肿瘤的首位死亡疾病，据统计大约57%的肺癌患者就诊时已经出现了远处转移，临床预后较差。抗肺癌转移是当前治疗晚期转移性肺癌的新方向和思路。既往研究表明肿瘤的生物学改变在一定程度上能够影响肿瘤的转移行为和侵袭扩散模式，而目前的基础及临床研究尚未阐明导致肺癌相关信号转导途径中发生特异性器官转移的分子机制，有关驱动基因突变与器官转移之间相关性的研究也较为罕见。本篇综述旨在对近几年有关非小细胞肺癌表皮生长因子受体（epidermal growth factor receptor, EGFR）、间变性淋巴瘤激酶（anaplastic lymphoma kinase, ALK）、Kristen鼠肉瘤病毒原癌基因同源体（V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue, KRAS）驱动基因表达的特点以及与转移器官分布之间相关性的文献进行小结。
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