Association between E469K polymorphism in the ICAM1 gene and the risk of diabetic nephropathy: a meta-analysis

Liya Liu,Dongling He,Ling Fang,Xiaojie Yan

doi:10.1186/s12944-018-0922-2

Abstract

BackgroundInflammation may be a key pathophysiological mechanism in diabetic nephropathy (DN). Intercellular adhesion molecule 1 (ICAM1) is an acute phase marker of inflammation. ICAM1 rs5498 has been reported to be associated with the risk of DN. However, the previous findings were conflicting due to the limited sample sizes, different methodologies and ethnicities. Therefore, this study aimed to investigate the genetic association between ICAM1 rs5498 and the risk of DN.MethodsTwo investigators independently searched the studies from the databases PubMed, Web of Science, the Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Embase. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the associations.ResultsNo significant association was detected between ICAM1 rs5498 and DN susceptibility in allelic and recessive models (p > 0.05). However, significant reduction of frequencies of the dominant model of ICAM1 rs5498 was only detected in the Caucasian subgroup (OR = 0.80; 95% CI = [0.65, 0.99], p = 0.04) and type 1 diabetes mellitus subgroup (OR = 0.80; 95% CI = [0.65, 0.99], p = 0.04).ConclusionsThus, ICAM1 rs5498 might be a risk factor for DN in Caucasians and type 1 diabetes mellitus patients, which suggested that ICAM1 rs5498 might help in early diagnosis and prevention of this disease. Further studies were needed to clarify the biochemical function and pathological role of ICAM1 rs5498 in the risk of DN.

Highlights

Diabetes mellitus (DM) is a metabolic disorder associated with chronic micro and macro vascular complications [1, 2]
Meta-analysis results After all the extracted data were pooled, a total of 1901 cases and 1847 controls were available for Intercellular adhesion molecule 1 (ICAM1) analysis
Subgroup analyses based on ethnicity, sample size, and type of DM were conducted

Summary

Introduction

Diabetes mellitus (DM) is a metabolic disorder associated with chronic micro and macro vascular complications [1, 2]. One of the worst chronic microvascular complication is diabetic nephropathy (DN) [3]. DN is the most common single cause of end-stage renal disease (ESRD) [6]. The patients with DN exhibit persistent proteinuria, hypertension, declining renal function, and increased premature mortality, primarily as a result of cardiovascular disease [7]. Multi-factorial diseases including genetic and environmental factors are known to influence DM and DN [8, 9]. Inflammation may be a key pathophysiological mechanism in diabetic nephropathy (DN). ICAM1 rs5498 has been reported to be associated with the risk of DN. This study aimed to investigate the genetic association between ICAM1 rs5498 and the risk of DN

Objectives

Methods

Results