Association between Dyslipidemia and Diabetic Nephropathy in Type 2 Diabetic Patients: A Cross-Sectional Study

Abstract

Introduction: Type 2 diabetes is a severe disease. It contains hormones that produce certain metabolic abnormalities and long-term problems. Urine contains low but abnormal levels of albumin which is the initial stage called “microalbuminuria”. Aim: To examine the association between dyslipidemia and diabetic nephropathy in type 2 diabetic patients. Methodology: Overall, 110 type 2 diabetic patients were involved in this study. Their detailed clinical history was evaluated along with clinical examination, urine albumin creatinine ratio, serum lipid profile. Data was analyzed using the Chi-square test and ANOVA test. It was done by the software EPICAL. A p-value less than 0.05 was considered significant.Study design: A cross-sectional study. Place and duration: This study was conducted at Bilawal Medical College for Boys at LUMHS Jamshoro Pakistan from June 2020 to June 2021. Results: A total of45 patients were having normoalbuminuria, 25 were having overt proteinuria, and the rest 40 patients had microalbuminuria. The most significant lipid abnormalities found in this study was increased LDL and increased triglyceride. Patients having Normoalbuminuria and overt proteinuria were compared and it was found that LDL and triglyceride had a positive correlation. As triglycerides increased, LDL also increased. Both had a p-value <0.001. Conclusion: Lipid abnormalities associated with diabetic nephropathy were increased low-density lipoprotein (LDL) and triglyceride.