Abstract
ObjectiveTo examine the cross-sectional associations between dietary magnesium (Mg) intake and radiographic knee osteoarthritis (OA), joint space narrowing (JSN), and osteophytes (OST) respectively.MethodsA total of 1626 subjects were included in the study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Radiographic knee OA was defined as Kellgren-Lawrence (K-L) Grade 2 in at least one leg. JSN and OST were assessed individually according to the Osteoarthritis Research Society International (OARSI) atlas. A multivariable logistic analysis model was applied to test the various associations after adjusting for potentially confounding factors.ResultsThe relative odds of radiographic knee OA were decreased by 0.53 times in the third quintile of Mg intake [odds ratio (OR) 0.53, 95% confidence interval (CI) 0.28–1.01], 0.40 times in the fourth quintile (OR 0.40, 95% CI 0.17–0.94) and 0.34 times in the fifth quintile (OR 0.34, 95% CI 0.11–1.00) compared with those in the lowest quintile, while P for trend was 0.111. The relative odds of JSN were decreased by 0.49 times in the third quintile of Mg intake (OR 0.49, 95% CI 0.28–0.88) and 0.37 times in the fifth quintile (OR 0.37, 95% CI 0.14–0.98) compared with those in the lowest quintile, while P for trend was 0.088. There was no significant relationship between dietary Mg intake and the presence of OST.ConclusionsThe findings of this cross-sectional study indicate that Mg intake is inversely associated with radiographic knee OA and JSN. It supports potential role of Mg in the prevention of knee OA.Level of EvidenceLevelIII, cross-sectional study.
Highlights
Osteoarthritis (OA) is a progressive rheumatic disease whose incidence is growing continuously with the aging populations in many societies
The relative odds of radiographic knee OA were decreased by 0.53 times in the third quintile of Mg intake [odds ratio (OR) 0.53, 95% confidence interval (CI) 0.28–1.01], 0.40 times in the fourth quintile and 0.34 times in the fifth quintile compared with those in the lowest quintile, while P for trend was 0.111
The relative odds of joint space narrowing (JSN) were decreased by 0.49 times in the third quintile of Mg intake and 0.37 times in the fifth quintile compared with those in the lowest quintile, while P for trend was 0.088
Summary
Osteoarthritis (OA) is a progressive rheumatic disease whose incidence is growing continuously with the aging populations in many societies. In Asia, the prevalence of knee OA ranges from 11.8% to 55.5% in those 40 years of age [1,2,3,4,5,6]. Along with the further increase in the prevalence of knee OA [7], there is an increasing rate of knee arthroplasty performed, which is currently the only effective treatment for the late phase of OA. This fact has made identification of effective conservative treatments and preventive methods a high priority. Effective therapies and prevention options for knee OA, are limited.
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