Abstract
Currently there are contradictory observations regarding the associations between the isoflavone intake and inflammatory bowel disease in terms of its prevention and treatment, and this may be attributed to the diversity of applied doses and influence of various isoflavones. The aim of the presented cross-sectional study is to analyze the association between intake of various isoflavones (daidzein, genistein, glicytein and total isoflavones) and ulcerative colitis symptoms (fecal blood, mucus and pus) in Polish Caucasian individuals in confirmed remission. Assessment of diet was based on self-reported data obtained from patients’ three-day dietary records and their individual assessments of symptoms. A total of 56 Caucasian patients with ulcerative colitis in confirmed remission were recruited for the study (37 females and 19 males, aged 18–80). For individuals with no fecal mucus observed, higher daidzein (p = 0.035, 122 vs. 19 µg) and total isoflavone intakes (p = 0.034, 302.2 vs. 123.7 µg) were observed in comparison with individuals not declaring this symptom, while for daidzein it was confirmed for the component density of their diets. The opposite association was stated for fecal pus, as for individuals with a lack of this symptom, lower daidzein intake was stated in comparison with individuals declaring this symptom (p = 0.049, 103.3 vs. 206.7 µg), but it was not confirmed for the component density of the diets. It was stated that the high intake of isoflavones by Caucasian individuals, as in a western diet, may influence the symptoms of ulcerative colitis, with the strongest influence by daidzein. Taking this into account, isoflavones may be included into the diets of ulcerative colitis patients in remission if well-tolerated, but there is a need for further study.
Highlights
Ulcerative colitis is a chronic idiopathic inflammatory disease affecting the colonic mucosa that typically extends proximally from the rectum [1]
The aim of the present study is to analyze the association between the intake of isoflavones and ulcerative colitis symptoms in Polish Caucasian individuals in confirmed remission
In this study, which was conducted among a group of individuals with ulcerative colitis, the most important observation was that patients declaring a lack of fecal mucus were characterized by a higher intake of daidzein and higher total isoflavone intake compared with patients declaring the presence of fecal mucus
Summary
Ulcerative colitis is a chronic idiopathic inflammatory disease affecting the colonic mucosa that typically extends proximally from the rectum [1]. The clinical course of ulcerative colitis is unpredictable and involves alternating periods of remission and exacerbation [2]. The exact etiology of the disease remains unclear, and the primary attributable causes are genetic predisposition, dysregulated immune response and environmental factors [3]. The symptoms depend on the severity and extent of the disease, one of the most frequent symptoms is diarrhea, which may be accompanied by observable blood, mucus or pus contents [4], and may be observed even in remission [5]. Medical therapy poses the first-line therapy for managing ulcerative colitis, diet is gaining significant interest as a non-pharmacological approach to manage the disease [8]
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