Association between Dietary Inflammatory Index and Sarcopenia in Crohn's Disease Patients.

Cenyu Wang,Yongmei Jiang,Xutong Liu,Jie Zhong,Yubei Gu,Yongmei Shi,Dongsheng Bian

doi:10.3390/nu14040901

Cenyu Wang, Yongmei Jiang + Show 5 more

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https://doi.org/10.3390/nu14040901

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Journal: Nutrients	Publication Date: Feb 21, 2022
Citations: 16	License type: CC BY 4.0

Affiliation: Shanghai Jiao Tong University, Ruijin Hospital

Abstract

Background: Chronic inflammation is a pathophysiological cause of sarcopenia in Crohn’s disease (CD) patients. However, the potential impact of diet-related inflammation on sarcopenia has not yet been adequately investigated. We examined the associations between Dietary Inflammatory Index (DII) and sarcopenia in CD patients. Methods: A total of 140 CD patients from Ruijin Hospital in Shanghai were included in this cross-sectional study. DII scores were calculated from the dietary data collected using a validated food frequency questionnaire (FFQ). Sarcopenia was determined according to the Asian Working Group for Sarcopenia. Multivariable logistic regression analyses were performed to determine the association between DII and sarcopenia. Results: The mean DII score was 0.81 ± 2.13, ranging from −3.24 to 4.89. The overall prevalence of sarcopenia was 26.4%. The higher DII score significantly increased the risk of sarcopenia in CD patients (ORQuartile4vs1: 9.59, 95% CI: 1.69, 54.42, ptrend = 0.031) in the multivariable model after adjusting for more potential confounders. Moreover, CD patients with a lower DII had a significantly higher appendicular skeletal muscle mass index (ASMI, ORQuartile4vs1: 5.48, 95% CI: 1.51, 19.87, ptrend = 0.018) after adjusting for age, gender, BMI, smoking status and drinking status model. Yet, there were no significant differences between DII and ASMI after adjusting for more potential confounders. Additionally, no significant association was observed between DII and handgrip strength in the multivariable-adjusted models. Conclusions: Pro-inflammatory diet was associated with increased risk of sarcopenia in CD patients. CD patients should have a proper intake of energy and protein. These patients could also benefit from supplementation with enteral nutrition due to its anti-inflammatory potential.

Highlights

Introduction published maps and institutional affilInflammatory bowel disease (IBD), which refers to Crohn’s disease (CD) and ulcerative colitis (UC) jointly, is the representative chronic inflammatory disease of the gastrointestinal system [1]
CD patients should have a proper intake of energy and protein
17 males and 20 females were diagnosed with sarcopenia

Summary

Introduction

Introduction published maps and institutional affilInflammatory bowel disease (IBD), which refers to Crohn’s disease (CD) and ulcerative colitis (UC) jointly, is the representative chronic inflammatory disease of the gastrointestinal system [1]. The global emergence of CD and UC has highlighted the impact of changing environmental factors on disease development in a particular diet. Food components can affect the incidence of IBD and its development through modulation of intestinal microbiota, intestinal immune system, and inflammation [2]. As most IBD patients reported specific changes in their diet, it is believed that dietary factors might exacerbate symptoms as well as inflammation [3,4]. Some researchers showed that the inflammatory state could be modulated by food components affecting the progression and exacerbation of IBD via their effect on inflammation [5,6,7]. De Vries et al showed that nearly 60% of IBD patients valued diet to be either more or important compared to their medicine, while more than 60% believed IBD decreases iations

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