Association between Dietary Fiber Intake and Incidence of Depression and Anxiety in Patients with Essential Hypertension.

Yuanyuan Liu,Xiaohua Wang,Ting Liu,Yunying Hou,Omorogieva Ojo,Xiaojiao Du,Yang Ju,Qing Wu,Lingling Cui

doi:10.3390/nu13114159

Yuanyuan Liu, Xiaohua Wang + Show 7 more

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https://doi.org/10.3390/nu13114159

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Journal: Nutrients	Publication Date: Nov 20, 2021
Citations: 16	License type: CC BY 4.0

Affiliation: Soochow University, University of Greenwich

Abstract

(1) Background: Our previous study found that the dietary fiber supplement in patients with hypertension increased SCFA-producers, Bififidobacterium and Spirillum in the gut microbiota, which may be associated with improvement of depression and anxiety through the gut–brain axis. However, only a few studies have explored the association between dietary fiber intake (DFI) and the incidence of depression and anxiety in hypertensive patients. (2) Methods: A cross-sectional survey was conducted in one comprehensive hospital and one community clinic aimed at understanding the status of DFI and the association between DFI and incidences of depression and anxiety in hypertensive patients. Levels of DFI were obtained through a two-24 h diet recall. According to the levels of DFI from low to high, the participants were divided into Q1, Q2, Q3 and Q4 groups. The Reported Outcomes Measurement Information System short form v1.0-Depression 8b and Anxiety 8a were used to assess patients’ levels of depression and anxiety. (3) Results: A total of 459 hypertensive patients were recruited and the daily DFI was 10.4 g. The incidences of hypertension combined with depression and anxiety were 19.6% and 18.5%, respectively. Regression analysis showed statistically significant associations between DFI and depression (B = −0.346, p = 0.001) and anxiety score (B = −0.565, p < 0.001). In logistic regression, after the covariates were adjusted, DFI was associated with the incidence of depression in Q3 (OR 2.641, 95% CI 1.050–6.640) and with that of anxiety in Q1 (OR 2.757, 95% CI 1.035–7.346), compared with Q4. (4) Conclusions: A higher consumption of DF was a protective factor for depression and anxiety in hypertensive patients.

Highlights

IntroductionHypertension and psychological comorbidities may share some common pathological mechanisms including the disorder of intestinal flora, high inflammatory response, and the excessive activation of the renin–angiotensin–aldosterone system (RAAS) [1,2,3]
This study aimed to investigate the status of DF intake and explore the associations between DF intake and psychological comorbidities in hypertensive patients
These results indicated that most hypertensive patients may not have sufficient dietary fiber intake in China

Summary

Introduction

Hypertension and psychological comorbidities may share some common pathological mechanisms including the disorder of intestinal flora, high inflammatory response, and the excessive activation of the renin–angiotensin–aldosterone system (RAAS) [1,2,3]. They are closely related, and often influence or even cause each other [3]. Carroll et al [5] found that the prevalences of depression and anxiety in hypertensive patients were 9% and 12%, respectively. In China, the prevalences of depression, anxiety, depression and anxiety comorbidities in patients with hypertension were as high as 47.9%, 63% and 36.4% [6]

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