Abstract
BackgroundHigher dietary acid load (DAL) was considered to be associated with an elevated risk of hypertension, while related data from mainland China remains scarce and incomplete. We aim to evaluate the association between DAL and the risk of hypertension among adults from South China.MethodsWe conducted a nutrition and health survey in Guangdong Province located in southern China from 2015 to 2017. A four-stage probability sampling method was utilized to select representative samples of citizens aged ≥18 years old. DAL was assessed by potential renal acid load (PRAL) and net endogenous acid production (NEAP). Participants were divided to 4 groups (Q1-Q4) according to the quartile points of PRAL or NEAP distributions. Generalized linear mixed effects models were applied to evaluate the association between DAL and the risk of hypertension.ResultsA total of 3501 individuals were eligible for this study and 45.9% was male participants. Hypertension rate was 30.7%. A higher PRAL was associated with higher prevalence rate of hypertension among the male (P-trend = 0.03). OR for Q2 was 1.34 (95%CI, 0.94–1.91), Q3 was 1.53 (95%CI = 1.08, 2.16) and Q4 was 1.51 (95%CI, 1.08–2.16) among the male. However, as for total participants, the female, the participants with ≤55 years or participants with > 55 years, the associations were lack of significance. With respect to association between NEAP and hypertension, non-significant results were identified.ConclusionsThe current study indicated male hypertension was associated with higher PRAL, while given to this study was cross-sectional design, further studies are warranted to verify the association.
Highlights
Higher dietary acid load (DAL) was considered to be associated with an elevated risk of hypertension, while related data from mainland China remains scarce and incomplete
Participants were divided to 4 groups according to the quartile points of DAL (PRAL and net endogenous acid production (NEAP)) distributions
A total of 3237 participants and 3233 participants were included in generalized linear mixed effects model for potential renal acid load (PRAL) and NEAP analysis, respectively, because 268 participants and 264 participants had abnormal high value of PRAL and NEAP or hypertension patients were not under control after taking antihypertensive drugs
Summary
Higher dietary acid load (DAL) was considered to be associated with an elevated risk of hypertension, while related data from mainland China remains scarce and incomplete. Findings from previous studies have estimated that above 750,000 There are both potentially adverse and preventive effects of dietary factors on hypertension. Chen et al BMC Public Health (2019) 19:1599 health-related dietary patterns, such as Mediterranean diets These dietary patterns are perceived to be associated with inflammation suppression, which are involved in biological pathways of preventive effect on hypertension [13]. Another possible mechanism comes to endogenous acid and base production [14]. People with habitually animal products might be much easier to get a chronic and mild metabolic acidosis because phosphorus-rich and sulfur-rich components from these food could provide proton load and lower pH value in blood [15, 16]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
