Abstract
Aims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan.Methods: This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival.Results: The percentages of patients with diabetes among the severe and critical COVID-19 cases were higher than those among the mild or general cases (89.2%, 10.8 vs. 0%, p = 0.001). However, patients with and without diabetes showed no difference in the follow-up period (p = 0.993). The mortality rate in patients with or without diabetes was 2.9% (n = 4) and 1.1% (n = 9), respectively (p = 0.114). Univariate and multivariate Cox regression analyses and the Kaplan-Meier curves did not show any statistically significant differences between patients with and without diabetes (all p > 0.05).Conclusions: Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. These results may be useful for clinicians in the management of diabetic patients with COVID-19.
Highlights
Coronavirus disease 2019 (COVID-19) cause by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) was first identified in Wuhan, China, and has subsequently and quickly spread to more than 70 countries, including the United States, Spain, and Italy [1, 2]
As an emergency specialty field hospital hosted by the Zhongnan hospital, Leishenshan Hospital was put into use in February to provide treatment for COVID-19 patients in Wuhan, marking a milestone in China’s battle against COVID19
We investigated the association between diabetes as a comorbidity and negative clinical courses and outcomes of COVID-19 in a large sample of patients from a single hospital in Wuhan, China
Summary
Coronavirus disease 2019 (COVID-19) cause by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) was first identified in Wuhan, China, and has subsequently and quickly spread to more than 70 countries, including the United States, Spain, and Italy [1, 2]. SARS-CoV-2 could cause severe, even lethal pneumonia and lung failure. As of April 25, 2020, more than 2,800,000 confirmed cases and 190,000 deaths of COVID-19 have been reported worldwide [3]. In Leishenshan Hospital, 1,880 patients were diagnosed with COVID-19 between February 8, 2020 and April 15, 2020. Among those patients, 139 cases had a previous diagnosis of diabetes mellitus
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