Abstract
BackgroundPatients with brain tumor are in risk of depression or depressive symptoms, but the estimated prevalence varies between studies. The aim of this study is to get a proper summarized estimate of depression prevalence in brain tumor patients.MethodsLiterature search on Pubmed, PsycINFO, and Cochrane library from January 1981 through October 2016. The prevalence of depression or depressive symptoms in brain tumor patients was estimated by screening scales and analyzed using stratified meta-analysis and subgroup analysis. The prevalence of depression level or symptoms during the follow-up periods was detected by secondary analysis.ResultsAmong the 37 studies included in this meta-analysis, 25 used a cross-sectional design and 12 used longitudinal study. The pooled prevalence was 21.7% (971/4518 individuals, 95 % confidence interval (CI) 18.2%–25.2%) for overall sample. Lower prevalence was detected in studies with sample size ≥100 than <100, lower grade tumor than high grade tumor, studies using clinician-rated depression scales than self-rated or non-depression-specific ones, and in patients from UK, Germany and Italy than USA. After analyzing 6 longitudinal studies, prevalence of depression remained no change in the follow-up periods. No significant differences were observed between study designs and tumor types.ConclusionsThe estimated prevalence of depression or depressive symptoms among brain tumor patients was 21.7%, affected by depression assessment type, sample size, tumor grade and country. Diagnosis and treatment of co-morbid depression in brain tumor patients need to be addressed in future studies for better life quality and oncology management.
Highlights
Depression is a severe mental health disorder developed under different circumstances, formally diagnosed by DSM-IV or DSM-V (Diagnostic and Statistical Manual of Mental Disorders 4th edition or 5th edition) [1, 2]
Among the 37 studies included in this meta-analysis, 25 used a crosssectional design and 12 used longitudinal study
Lower prevalence was detected in studies with sample size ≥100 than
Summary
Depression is a severe mental health disorder developed under different circumstances, formally diagnosed by DSM-IV or DSM-V (Diagnostic and Statistical Manual of Mental Disorders 4th edition or 5th edition) [1, 2]. Depressive symptoms, such as fatigue, loss of interest, decreased energy, feelings of guilt, worthlessness could be main manifestations of depressive disorder or other psychological diseases [1, 2]. The aim of our study is to acquire a proper summary estimate of the depression prevalence and to discuss the reasonable and suitable depression assessment instruments in the clinical setting. The aim of this study is to get a proper summarized estimate of depression prevalence in brain tumor patients
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