Abstract
BackgroundCoronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia.MethodsThis retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divided into COVID-19 with pneumonia and without pneumonia. CT severity score and PaO2/FiO2 ratio were used to assess lung injury.Results106 patients with 12 COVID-19 without pneumonia and 94 COVID-19 with pneumonia were included. Compared with COVID-19 without pneumonia, COVID-19 with pneumonia had significantly higher serum interleukin (IL)-2R, IL-6, and tumor necrosis factor (TNF)-α. Correlation analysis showed that CT severity score and PaO2/FiO2 were significantly correlated with age, presence of any coexisting disorder, lymphocyte count, procalcitonin, IL-2R, and IL-6. In multivariate analysis, log IL6 was the only independent explanatory variables for CT severity score (β = 0.397, p < 0.001) and PaO2/FiO2 (β = − 0.434, p = 0.003).ConclusionsElevation of circulating cytokines was significantly associated with presence of pneumonia in COVID-19 and the severity of lung injury in COVID-19 pneumonia. Circulating IL-6 independently predicted the severity of lung injury in COVID-19 pneumonia.
Highlights
Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
It was confirmed that the disease was caused by a novel coronavirus which was named severe acute respiratory syndrome coronavirus 2
In the present retrospective study, we focused on the relationship between cytokine profiles and lung injury in COVID-19 pneumonia patients
Summary
The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia. We aimed to compare cytokine profiles between COVID-19 patients with pneumonia and without pneumonia. We aimed to evaluate the relationship between cytokine profiles and lung injury assessed by computed tomographic (CT) findings and PaO2/FiO2 ratio in COVID-19 patients with pneumonia. We aimed to evaluate the role of cytokines in lung injury in COVID19 patients and attempted to find out a potential therapeutic target for the management lung injury in COVID-19 pneumonia
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