Association between CYP1A1 Ile462Val (m2, A2455G, rs1048943) polymorphism and head and neck cancer susceptibility: A meta-analysis, meta-regression, and trial sequential analysis

Abstract

BackgroundGenetics contribute to head and neck cancer (HNC) susceptibility, as has been indicated in genome-wide association studies. We aimed to appraise the association between CYP1A1 Ile462Val and HNC susceptibility. MethodsThe databases of PubMed/MEDLINE, Web of Science, Cochrane Library, and Scopus were investigated until March 31, 2021. To evaluate the association, odds ratios (ORs) and 95% confidence intervals (CIs) based on five genetic models were used by the RevMan 5.3 software. The subgroup and sensitivity analyses, trial sequential analysis (TSA), and publication bias were different types of analyses applied on the pooled ORs. The quality score was done according to a modified questionnaire. ResultsA total of 501 records were recognized through the databases. After careful selection, 32 studies were entered into the meta-analysis. The pooled results showed that the Val allele and Val/Val and Ile/Val genotypes were related to high risk to develop HNC. Different factors such as ethnicity, the source of controls, and tumor type could play a further role in the relationship between the HNC susceptibility and CYP1A1 Ile462Val polymorphism. TSA showed that the CYP1A1 Ile462Val polymorphism was related to the HNC risk with enough samples. ConclusionThe main finding demonstrated that the Val allele, Val/Val and Ile/Val genotypes of CYP1A1 Ile462Val polymorphism were related to high risk in HNC patients, mainly oral and pharyngeal cancers.