Association between CYP1A1 Gene Polymorphisms and Cervical Cancer Susceptibility: A Meta-Analysis

Abstract

IntroductionThis study is to systemically analyze the association of CYP1A1 gene MspI and Ile462Val polymorphisms with cervical cancer susceptibility.Material and methodsThe literatures about the associations between CYP1A1 polymorphism and cervical cancer were retrieved through PubMed, Embase, Chinese biomedical literature database, Wanfang database, Database of Chinese Scientific and Technical Periodicals (VIP) and China Knowledge Network. Hardy-Weinberg equilibrium test was used to evaluate the quality of the included studies, and the data in the studies selected were analyzed by Stata 12.0 software. Potential publication bias was assessed with funnel plots and a modified Egger’s linear regression test.ResultsA total of 17 studies were enrolled in this analysis. There were 14 articles on MspI locus polymorphism, including 2448 cases and 2520 controls. We found significant association between MspI locus polymorphism and cervical cancer susceptibility (C vs. T, OR 1.333, 95% CI 1.214-1.464, P≤0.001; CC vs. TT, OR 1.962, 95% CI 1.571-2.450, P≤0.001; CC/CT vs.TT, OR1.591, 95% CI1.406-1.800, P≤0.001; CCvs.TT/CT,OR1.429, 95% CI 1.177-1.736, P≤0.001). Totally, 11 articles, including 2137 cases and 2116 controls, analyzed the Ile462Val locus polymorphism and the risk of cervical cancer. The result showed significant association between Ile462Val locus polymorphism and cervical cancer susceptibility (Val vs. Ile, OR 1.338, 95% CI 1.199-1.493, P≤0.001; ValVal vs. IleIle, OR 1.576, 95% CI 1.188-2.090, P=0.002; ValVal/ValIle vs. IleIle, OR 1.498; 95% CI 1.299-1.728, P≤0.001).ConclusionsBoth MspI and Ile462Val polymorphisms of CYP1A1 gene are associated with the risk of cervical cancer.