Abstract
BackgroundAssociation between Cyclin D1 (CCND1) polymorphism and cervical cancer risk are conflicting with published articles. We performed a meta-analysis to investigate the association between CCND1 G870A polymorphism and cervical cancer risk.MethodsPubMed, Embase and CNKI data were researched to conduct a meta-analysis on the associations between CCND1 G870A polymorphism and cervical cancer risk. Ten published case–control studies including 2,864 patients with cervical cancer and 3,898 controls were collected in this meta-analysis. Odds ratio (OR) with 95% confidence interval (CI) were applied to assess the relationship; meta-regression, sensitivity analysis and cumulative analysis were also conducted to guarantee the strength of results.ResultsOverall, no significant association between CCND1 G870A polymorphism and cervical cancer risk were found in allele contrast (A vs. G: OR = 1.02, 95% CI = 0.88-1.19, P = 0.76 I2 = 74.5%), codominant model (GA vs. GG: OR = 0.98, 95% CI = 0.77-1.26, P = 0.90 I2 = 69.1%; AA vs GG: OR = 1.03, 95% CI = 0.75-1.41, P = 0.85 I2 = 75.9%), dominant model (GA + AA vs. GG: OR = 1.00, 95% CI = 0.78-1.28, P = 0.99 I2 = 72.3%) and recessive model (AA vs GG + GA: OR = 1.06, 95% CI = 0.85-1.23, P = 0.62, I2 = 70.1%). Similarly, in the stratified analysis by ethnicity, study design and genotyping type, no significant association detected in all genetic models either.ConclusionsOur meta-analysis indicated that CCND1 G870A might be not the crucial risk factor for the development of cervical cancer.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_168
Highlights
Association between Cyclin D1 (CCND1) polymorphism and cervical cancer risk are conflicting with published articles
New molecular epidemical studies revealed that human papillomavirus (HPV), HPV 16 and 18 infections may be the common and important factor contributing to the development of cervical cancer, which is known to cause approximately 70% of cervical cancers [2,3]
Several studies have found that amplification of CCND1 and the aberrant expression of protein are associated with cell proliferation and poor prognosis in some cancers, such as head and neck cancer [6], lung cancer [7], and breast cancer [8]
Summary
Association between Cyclin D1 (CCND1) polymorphism and cervical cancer risk are conflicting with published articles. We performed a meta-analysis to investigate the association between CCND1 G870A polymorphism and cervical cancer risk. New molecular epidemical studies revealed that human papillomavirus (HPV), HPV 16 and 18 infections may be the common and important factor contributing to the development of cervical cancer, which is known to cause approximately 70% of cervical cancers [2,3]. Several studies have found that amplification of CCND1 and the aberrant expression of protein are associated with cell proliferation and poor prognosis in some cancers, such as head and neck cancer [6], lung cancer [7], and breast cancer [8]
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