Abstract

No theoretical model explaining craniomandibular disorders has been generally accepted, despite the large number of studies on its etiology. This article suggests that one reason for the lack of a well-structured causal explanation could be associated with the study design most often used: cross-sectional studies of samples representative of a base population. Variation in the number of interferences was increased among the subjects by eliminating occlusal interferences annually in the treatment group (n = 53). The control group (n = 46) underwent placebo treatment. A double-blind design was used throughout the 3-year study. A cross-sectional analysis in the third year disclosed a significant association between the number of interferences and the signs of craniomandibular disorders. The results suggest that the absence of interference-free subjects in nonselected samples can be one explanation for the lack of association reported in most studies.

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