Abstract
Background: Colorectal neoplasm, including colorectal adenoma, is associated with old age, cigarette smoking, and the presence of metabolic syndromes. These are also risk factors for cardiovascular disease. Carotid ultrasonography is a noninvasive test that can predict the risk of cardiovascular disease and may be another test that may provide indications of these risk factors. This study aimed to investigate the association between colorectal adenomatous polyps and carotid atherosclerosis. Methods: This study included 548 adults who underwent colonoscopy and carotid ultrasonography for a health examination between March 2013 and December 2017 at a university hospital in South Korea. Abnormal carotid sonography findings included either increased carotid intima-media thickness or presence of carotid plaques. Results: The proportion of subjects with overall colorectal adenomatous polyps was 31.0% (170/548). Colorectal adenoma was more prevalent in the presence of abnormal carotid ultrasonography findings (38.6% vs. 27.6%, p = 0.013). Colorectal adenomatous polyp was significantly associated with abnormal carotid ultrasonography findings (OR = 1.65; 95% CI, 1.12–2.42, p = 0.011) in a multivariate analysis after adjusting for age, sex, cigarette smoking, alcohol consumption, and presence of metabolic syndrome. Conclusion: Colorectal adenoma is significantly associated with carotid atherosclerosis.
Highlights
Colorectal cancer (CRC) is the third-most commonly diagnosed cancer in both men and women and the second leading cause of cancer-related death worldwide [1]
Carotid artery sonography has been commonly used as a noninvasive test that can predict the risk of cardiovascular disease (CVD) and may be another test for the identification of these risk factors
Colorectal adenoma was significantly associated with a higher mean body mass index (BMI), waist circumference, and triglyceride, fasting glucose, and glycated hemoglobin (HbA1c) levels, and a lower mean high-density lipoprotein (HDL) cholesterol level
Summary
Colorectal cancer (CRC) is the third-most commonly diagnosed cancer in both men and women and the second leading cause of cancer-related death worldwide [1]. Cardiovascular disease (CVD) shares common risk factors with CRC, such as old age, cigarette smoking, sedentary lifestyle, high-fat diet, and presence of metabolic syndrome. Carotid artery disease has been associated with CVD and an increased risk of cardiovascular (CV) events [8,9]. Carotid artery sonography has been commonly used as a noninvasive test that can predict the risk of CVD and may be another test for the identification of these risk factors. Colorectal neoplasm, including colorectal adenoma, is associated with old age, cigarette smoking, and the presence of metabolic syndromes. These are risk factors for cardiovascular disease.
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