Abstract
Majority of patients with 2019 novel coronavirus infection (COVID-19) exhibit mild symptoms. Identification of COVID-19 patients with mild symptoms who might develop into severe or critical illness is essential to save lives. We conducted an observational study in a dedicated make-shift hospital for adult male COVID-19 patients with mild symptoms between February and March 2020. Baseline characteristics, medical history, and clinical presentation were recorded. Laboratory tests and chest computed tomography were performed. Patients were observed until they were either transferred to a hospital for advanced care owing to disease exacerbation or were discharged after improvement. Patients were grouped based on their chest imaging findings or short-term outcomes. A total of 125 COVID-19 patients with mild symptoms were enrolled. Of these, 7 patients were transferred for advanced care while 118 patients were discharged after improvement and showed no disease recurrence during an additional 28-day follow-up period. Eighty-five patients (68.0%) had abnormal chest imaging findings. Patients with abnormal chest imaging findings were more likely to have disease deterioration and require advanced care as compared to those with normal chest imaging findings. Patients with deteriorated outcomes were more likely to have low peripheral blood oxygen saturation and moderately-elevated body temperature. There were no significant differences between patients with deteriorated or improved outcomes with respect to age, comorbidities, or other clinical symptoms (including nasal congestion, sore throat, cough, hemoptysis, sputum production, shortness of breath, fatigue, headache, nausea or vomiting, diarrhea). Abnormal chest imaging findings, low peripheral blood oxygen saturation, and elevated temperature were associated with disease deterioration in adult male COVID-19 patients with mild clinical symptoms.Clinical Trial Registration: https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S0009RA3&selectaction=Edit&uid=U0003F4L&ts=2&cx=-ajpsbw, identifier NCT04346602.
Highlights
In December 2019, an outbreak of novel coronavirus pneumonia was reported in Wuhan, China
The human disease caused by this novel coronavirus is referred to as COVID19, which was declared as a pandemic by World Health Organization (WHO) [3]
A total of 309 patients were admitted to our mobile cabin hospital during the study reference period
Summary
In December 2019, an outbreak of novel coronavirus pneumonia was reported in Wuhan, China. The World Health Organization (WHO) named this new coronavirus as “2019 Novel Coronavirus (2019-nCoV)” [2]. Several studies have investigated the epidemiology, pathogenesis, and the management of COVID-19 Most of these studies involved hospitalized patients with moderate or critical illness [5,6,7,8]. It is important to identify patients who have mild initial presenting symptoms, but who are at high risk of developing severe illness. This would help optimize the use of medical resources and reduce the associated morbidity and mortality
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