Abstract
BackgroundChymase is the major angiotensin II (Ang II)-forming enzyme in cardiovascular tissue, with an important role in atrial remodeling. This study aimed to examine the association between chymase 1 gene (CMA1) polymorphisms and atrial fibrillation (AF) in a Chinese Han population.MethodsThis case-control study enrolled 126 patients with lone AF and 120 age- and sex-matched healthy controls, all from a Chinese Han population. Five CMA1 polymorphisms were genotyped.ResultsThe CMA1 polymorphism rs1800875 (G-1903A) was associated with AF. The frequency of the GG genotype was significantly higher in AF patients compared with controls (p = 0.009). Haplotype analysis further demonstrated an increased risk of AF associated with the rs1800875-G haplotype (Hap8 TGTTG, odds ratio (OR) = 1.668, 95% CI 1.132–2.458, p = 0.009), and a decreased risk for the rs1800875-A haplotype (Hap5 TATTG, OR = 0.178, 95% CI 0.042–0.749, p = 0.008).ConclusionsCMA1 polymorphisms may be associated with AF, and the rs1800875 GG genotype might be a susceptibility factor for AF in the Chinese Han population.
Highlights
Chymase is the major angiotensin Angiotensin II (II) (Ang II)-forming enzyme in cardiovascular tissue, with an important role in atrial remodeling
Diverse structural heart diseases and systemic disorders have been associated with atrial fibrillation (AF), including valvular heart disease, ischemic heart disease, congestive heart failure, cardiomyopathy, pulmonary heart disease, cardiothoracic surgery, essential hypertension, and hyperthyroidism [1, 2], while age, obesity, obstructive sleep apnea–hypopnea syndrome, smoking, excessive drinking, and drug or toxicant use are considered to contribute to the development of AF [1, 3]
The Framingham Heart Study showed that 30% of participants with AF had at least one parent with AF, and individuals with at least one parent suffering from AF had an approximately 40% increased risk of developing AF, after adjusting for age, sex, blood pressure, diabetes, and clinically overt heart disease [5]
Summary
Chymase is the major angiotensin II (Ang II)-forming enzyme in cardiovascular tissue, with an important role in atrial remodeling. The Framingham Heart Study showed that 30% of participants with AF had at least one parent with AF, and individuals with at least one parent suffering from AF had an approximately 40% increased risk of developing AF, after adjusting for age, sex, blood pressure, diabetes, and clinically overt heart disease [5]. These facts indicate a potential role for genetic variations in the pathogenesis of AF. The genetic basis of AF pathogenesis is complex, involving modest contributions to disease risk from genetic variations in many genes, and further studies are needed to clarify the genetic determinants of AF risk
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