Abstract
This study explored the relation between Ménière’s disease and chronic obstructive pulmonary disease (COPD). The ≥40-year-old population of the Korean National Health Insurance Service-Health Screening Cohort was included. In total, 7734 Ménière’s disease patients and 30,936 control participants were enrolled. Control participants were matched for age, sex, income, and region of residence with Ménière’s disease participants. The odds of having Ménière’s disease given a history of COPD were analyzed using conditional logistic regression. Subgroup analyses were conducted according to age, sex, income, and region of residence. The odds of having Ménière’s disease were found to be 1.18-fold higher with a history of COPD than with no history of COPD (95% confidence intervals (CI) = 1.06–1.32, E-value (CI) = 1.64 (1.31)). The ≥60 years old, male, low-income, and rural subgroups showed increased odds of developing Ménière’s disease when a history of COPD was reported. A history of COPD was associated with an increased risk of Ménière’s disease in the adult population.
Highlights
Chronic obstructive pulmonary disease (COPD) is a chronic obstructive airway disease with a prevalence of approximately 10.1% worldwide [1]
COPD is more common in men than in women, and mortality due to COPD occurs mainly in low- to middle-income countries [2]
COPD is ranked as having the third highest burden for a disease of mortality worldwide [3]
Summary
Chronic obstructive pulmonary disease (COPD) is a chronic obstructive airway disease with a prevalence of approximately 10.1% worldwide [1]. COPD is ranked as having the third highest burden for a disease of mortality worldwide [3]. With an aging population, the disease burden of COPD has been increasing [4]. COPD is a heterogeneous and complex disease [5], progressive airway inflammation and an impaired immune response are common pathologies in patients with COPD [6,7]. COPD shares risk factors, including aging, smoking, inflammation, and physical inactivity, with other comorbidities, such as cardiovascular disease, osteoporosis, and depression [8]. COPD has been suggested to increase the risk of these comorbidities via aggravation of inflammatory and immune responses and physical inactivity [7]
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