Association between Chronic Kidney Disease and Non-Alcoholic Fatty Liver Disease: A Cross Sectional Study

Abstract

Abstract Background The concept of chronic kidney disease (CKD) continues to evolve from a common pathway initiated by unrelated diseases into a number of complications and adaptations that affect the function of every organ. Non-alcoholic fatty liver disease (NAFLD) is a public health problem worldwide. Evidence linking NAFLD to the development and progression of CKD is emerging as a popular area of scientific interest. NAFLD and CKD are associated with poor outcomes and high costs; they have become major public health problems. Aim of the Work To assess the prevalence of NAFLD in CKD patients Patients and Methods This was a retrospective cross-sectional study that was conducted on patients with CKD at the National Institute of Urology and Nephrology, Cairo, Egypt. Results Our study revealed that, there was highly statistically significant increase among NAFLD Group than No NAFLD Group regarding CKD stages. Also, there was statistically significant increase among NAFLD Group than No NAFLD Group regarding Obesity and Hypertension, and there was highly statistically significant increase among NAFLD Group than No NAFLD Group regarding metabolic syndrome, and there was no statistically significant difference between the non NAFLD Group and NAFLD Group regarding Diabetes. Conclusion NAFLD and NAFLD with traditional comorbidities are associated with the risk of prevalence of CKD. It is recommended that patients with NAFLD, especially those with coexisting comorbidities, should be carefully accessed for the development of CKD. Future studies should focus on the mechanisms and therapeutic targets for both NAFLD and CKD in a comorbid setting.