ASSOCIATION BETWEEN CHINESE VISCERAL ADIPOSITY INDEX AND RISK OF CARDIOMETABOLIC MULTIMORBIDITY IN MIDDLE-AGED AND ELDERLY CHINESE POPULATION: EVIDENCE FROM A NATIONAL COHORT STUDY

Abstract

Objective: This cohort study was designed to investigate the associations between Chinese visceral adiposity index (CVAI) and Cardiometabolic multimorbidity (CMM) among middle-aged and elderly Chinese population. Design and method: A national cohort study that consisted of 6419 participants was conducted during a median follow-up time of 4 years. Three obesity- and lipid-related indices, including visceral adiposity index (VAI), Chinese visceral adiposity index (CVAI), lipid accumulation product (LAP) were recorded. Our study used multivariate adjusted Cox proportional hazard models, sensitivity analysis and restricted cubic spline analysis to investigate the associations of the Chinese visceral adiposity index with Cardiometabolic multimorbidity. Results were reported in log-relative hazard ratios and associated 95% CIs. Results: Of the 6686 participants included in the analysis, 6419 participants did not develop CMM and incident CMM occurred in 267 participants during the study period. Using multivariable-adjusted restricted cubic spline analyses, it was found that there was a significant nonlinear relationship between the levels of CVAI and the incidence of cardiometabolic multimorbidity (P<0.0001). The risk of CMM gradually increased when the CVAI increased, and rapid upward after exceeding 91.2. After adjustment of multiple covariates, a U-shaped association between CVAI and CMM was evident in all participants. The HR of CVAI gradually increases and is positively correlated with the increase of CVAI. Conclusions: The CVAI are independent predictors of CMM in the middle-aged and elderly Chinese population. Higher CVAI is positively associated with CMM risk.