Abstract
BackgroundThis retrospective study investigated the association between the Charlson comorbidity index (CCI) score and the survival of patients with stage IIIB-IV (advanced, non-resectable) non-small cell lung cancer (NSCLC) who also did not have gene mutations in epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK).MethodsThe records of 165 patients (28–80 y, median 61 y) who met the above criteria and were admitted to Beijing Friendship Hospital Capital Medical University from 1 May 2010 to 1 October 2014were reviewed. Associations between baseline variables and the CCI score were assessed via univariate and multivariate logistic regression analysis. Overall survival was defined as the time from the first clinic visit to death from any cause, or to the end of follow-up. Survival curves were estimated via the Kaplan-Meier method and compared with the log-rank test.ResultsLogistic regression analyses indicated that smoking and performance status were independently associated with the CCI score. Smoking was associated with an increased risk of mortality (odds ratio (OR) 4.12 (95% confidence interval [CI] 1.92–8.84) compared to non-smokers), as was performance status 2 (ambulatory, capable of self-care, unable to perform any work activities; active for >50% of waking hours) (OR 2.22 (95% CI, 1.14–4.33) compared to performance status 1). Univariate Cox’s regression analyses showed that the hazard ratios were significantly associated with the CCI score (P = 0.009), smoking (P = 0.042), and male gender (P = 0.021).ConclusionThe CCI score is an important prognostic factor for the prediction of overall survival in patients with stage IIIB-IV NSCLC who are negative for EGFR and ALK gene mutations.
Highlights
This retrospective study investigated the association between the Charlson comorbidity index (CCI) score and the survival of patients with stage IIIB-IV non-small cell lung cancer (NSCLC) who did not have gene mutations in epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK)
132 patients were excluded for being positive for EGFR or ALK gene mutations, having received radiotherapy in the lung area, having a performance status level of ≥3, or being lost early during follow-up
We evaluated whether the CCI score can be used to predict chemotherapy benefit and survival in patients with unresectable stage IIIB-IV NSCLC
Summary
This retrospective study investigated the association between the Charlson comorbidity index (CCI) score and the survival of patients with stage IIIB-IV (advanced, non-resectable) non-small cell lung cancer (NSCLC) who did not have gene mutations in epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK). Non-small cell lung cancer (NSCLC) is a common malignant tumour worldwide [1]. The use of comorbidities for prognostic assessment has been extensively studied in many fields [9, 10], including oncology [11,12,13]. The CCI was originally derived for hospitalized patients in general (internal) medicine, but revised versions have since been validated in multiple patient populations, including patients with NSCLC [15,16,17,18]
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