Association between Cervix Intraepithelial Neoplasia (CIN) and High-Risk Human Papillomavirus (HPV) Genotypes in Iraqi Women

Abstract

Human Papillomavirus (HPV) is an oncogenic virus that primarily causes premalignant and malignant cervical lesions particularly infection with high-risk types of viruses. Cervical cancer (CC) is a common gynecological tumor, ranking second in the female reproductive system tumor, particularly in women from developing countries. The prevalent and genotyping of high-risk HPV among Iraqi women during various stages of cervical lesions and cervical cancer were examined by using a real-time PCR. Results of this work revealed that the prevalence of HPV infection in women suffering from gynecological problem was 43%. The distribution of the high-risk HPV was relatively high for both HR-HPV-16 (44.90%) and HR-HPV-39 (14.29%), with HR-HPV-16 is being the most common. The finding of this study can be used to manage HPV infection and cervical cancer particularly at earlier stages of cervical lesions.