Abstract
Background:This study aimed to discover the association between parameters of event-related potentials (ERPs) and categorization of images of visual scenes, both emotionally-charged and neutral, in carriers of different genotypes of the COMT, HTR2A, BDNF genes. Methods:Electroencephalogram (EEG) and ERPs were recorded at 128 leads, with two ear referents. Images of different visual scenes were presented to the study participants sequentially on a monitor screen. The participants' task was to examine these images and indicate what emotions (negative, neutral or positive) they elicit. Comparison of event-related potentials was carried out using unpaired Student t-test in EEGLAB toolbox. Results:COMT. A stronger reaction, as reflected in the amplitude of the ERPs, in participants with the recessive homozygous Met/Met genotype was observed on latency around 200 ms to the stimuli, assessed as positive. Carriers of dominant homozygous Val/Val genotype had higher amplitude of 200 ms peak when assessed scene images as either neutral or negative in comparison to other genotypes. Participant with the Val/Met heterozygous genotype had higher amplitude of ERP that Met/Met group on same latency when assessed stimuli as negative. HTR2A . Significant increase in negativity in the parietal-occipital regions revealed in the range of 350-420 ms in participants with the recessive homozygous A/A genotype when choosing any type of assessment, compared to carriers of the heterozygous genotype A/G and the dominant homozygous G/G genotype. BDNF. Participants with Val/Val genotype categorized the visual images more thoroughly, as reflected in greater activation of the parietal-occipital zones and higher amplitude on ERP peak on 190 ms (negative assessment) and 160 ms (neutral assessment) then Val/Met carriers. Conclusions:The COMT, HTR2A, BDNF gene different genotypes are associated with the process of categorizing emotionally charged and neutral visual scenes, and this relationship is reflected in the ERP parameters.
Highlights
Studying hereditary factors that determine specifics of the categorization of visual images are very important for opening up new opportunities for individualizing educational experiences, i.e. those that could take into account individual visual characteristics of students
We studied specific parameters of event-related potentials (ERPs) and categorization of images of visual scenes, both emotionally-charged and neutral, in carriers of different genotypes of COMT, HTR2A, BDNF genes
Hardy-Weinberg equilibrium verification results The results of estimating the frequency distribution of alleles and genotypes of the COMT, BDNF and HTR2A genes polymorphisms corresponded to the Hardy-Weinberg distribution
Summary
Studying hereditary factors that determine specifics of the categorization of visual images are very important for opening up new opportunities for individualizing educational experiences, i.e. those that could take into account individual visual characteristics of students. Emotions that actualize these visual images can play an essential role in the process of categorizing visual scenes As it was shown in our previous work, particular features of image categorization may vary dependent on genetic differences among carriers at the level of genes that control the functioning of brain neurotransmitter systems (Ermakov et al, 2017; Kovsh et al, 2018). We studied specific parameters of event-related potentials (ERPs) and categorization of images of visual scenes, both emotionally-charged and neutral, in carriers of different genotypes of COMT, HTR2A, BDNF genes. This study aimed to discover the association between parameters of event-related potentials (ERPs) and categorization of images of visual scenes, both emotionally-charged and neutral, in carriers of different genotypes of the COMT, HTR2A, BDNF genes. Significant increase in negativity in the parietal-occipital regions revealed in the range of 350-420 ms in participants with the recessive homozygous A/A genotype when choosing any type of version 2
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