Abstract
Background Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited. Methods This study evaluated the association of underlying CV conditions with disease progression in patients with mild COVID-19. The primary outcome was the need to be transferred to the designated hospital for intensive care due to COVID-19 disease progression. The patients were divided into with and without CV conditions as well as stable and intensive care groups. Results Of the 332 patients with mild COVID-19, the median age was 51 years (IQR, 40-59 years), and 200 (61.2%) were female. Of the 48 (14.5%) patients with CV conditions, 23 (47.9%) progressed to severe disease status and required intensive care. Compared with patients without CV conditions, patients with CV conditions were older and more likely to have fatigue, chest tightness, and myalgia. The rate of requiring intensive care was significantly higher among patients with CV conditions than in patients without CV conditions (47.92% vs. 12.4%; P < 0.001). In subgroup analysis, the rate of requiring intensive care was also higher among patients with either hypertension or coronary heart disease (CHD) than in patients without hypertension or CHD. The multivariable regression model showed that CV condition served as an independent risk factor for intensive care (odds ratio (OR), 2.652 (95% CI, 1.019-6.899)) after adjustment for various cofounders. Conclusions Patients with mild COVID-19 complicating CV conditions are susceptible to develop severe disease status and requirement for intensive care.
Highlights
The outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus [1], rapidly progressed to a pandemic and was declared a public health concern [2]
We report the clinical characteristics and factors associated with developing severe disease after admission in patients hospitalized into temporary hospitals [12] with mild COVID-19
Of all 394 patients in the medical record system, who were screened initially from February 5, 2020, to March 10, 2020, 43 patients without available medical information and duplicated records and 19 patients who transferred to the designated hospital because of non-COVID-19 clinical factors were excluded (8 patients requested for referral by themselves, 6 patients with anxiety and insomnia, 1 patient with manic depression, 1 patient with dysgnosia, 1 patient with chickenpox, 1 patient with acute renal colic, and 1 patient with lumbar disc herniation)
Summary
The outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus [1], rapidly progressed to a pandemic and was declared a public health concern [2]. Information on factors affecting disease progression among patients with mild COVID-19 is limited. Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus disease 2019 (COVID-19) is limited. This study evaluated the association of underlying CV conditions with disease progression in patients with mild COVID-19. Of the 48 (14.5%) patients with CV conditions, 23 (47.9%) progressed to severe disease status and required intensive care. The rate of requiring intensive care was significantly higher among patients with CV conditions than in patients without CV conditions (47.92% vs 12.4%; P < 0:001). The rate of requiring intensive care was higher among patients with either hypertension or coronary heart disease (CHD) than in patients without hypertension or CHD. Patients with mild COVID-19 complicating CV conditions are susceptible to develop severe disease status and requirement for intensive care
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