Abstract
Cardiac natriuretic peptides (NPs) play a fundamental role in maintaining cardiovascular (CV) and renal homeostasis. Moreover, they also affect glucose and lipid metabolism. We performed a systematic review and meta-analysis of studies investigating the association of NPs with serum lipid profile. A PubMed and Scopus search (2005–2018) revealed 48 studies reporting the association between NPs and components of lipid profile [total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc) and triglycerides (TG)]. Despite high inconsistency across studies, NPs levels were inversely associated with TC [k = 32; pooled r = −0.09; I2 = 90.26%], LDLc [k = 31; pooled r = −0.09; I2 = 82.38%] and TG [k = 46; pooled r = −0.11; I2 = 94.14%], while they were directly associated with HDLc [k = 41; pooled r = 0.06; I2 = 87.94%]. The relationship with LDLc, HDLc and TG lost significance if only studies on special populations (works including subjects with relevant acute or chronic conditions that could have significantly affected the circulating levels of NPs or lipid profile) or low-quality studies were taken into account. The present study highlights an association between higher NP levels and a favorable lipid profile. This confirms and extends our understanding of the metabolic properties of cardiac NPs and their potential in CV prevention.
Highlights
Www.nature.com/scientificreports resistance, lower blood pressure, higher levels of high-density lipoprotein cholesterol (HDLc)]11,12
Studies were eligible for inclusion if they were observational studies or clinical trials investigating the association between cardiac natriuretic peptides (NPs) and components of lipid profile (TC, low-density lipoprotein cholesterol (LDLc), HDLc and TG)
We found two studies that have not been included in the meta-analysis due to the lack of usable data
Summary
Www.nature.com/scientificreports resistance, lower blood pressure, higher levels of high-density lipoprotein cholesterol (HDLc)]11,12. The several studies that evaluated the relationship between circulating levels of cardiac NPs and the main components of serum lipid profile have led to mixed results. The association appears to be restricted only to certain components of the lipid profile, with a discrepancy between one study and another. Many studies have a small sample size, which limits their strength of scientific evidence. On this basis, we performed a systematic review and meta-analysis of studies that evaluated the association between circulating cardiac NPs (A-type NPs and B-type NPs) levels and serum lipid profile, to comprehensively assess how the circulating levels of these hormones associate with serum total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), HDLc and triglycerides (TG)
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