Association between bone turnover markers and metabolic syndrome among men in Henan Province

Abstract

Objective To assess associations of bone turnover markers with metabolic syndrome (MS) among men in Henan Province. Methods From December 2015 to March 2016, a total of 697 male subjects were selected from the TIDE (Thyroid Disorders, lodine status and Diabetes: a National Epidemiological Survey-2014) research--Henan sub-center survey using multistage stratified cluster random sampling. All included subjects received standard oral glucose tolerance test, a physical examination (height, weight, waist circumference and blood pressure), a collection of blood samples to determine the level of plasma glucose, glycated hemoglobin A1c, total cholesterol, triglyceride (TG), high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, osteocalcin, pro-collagen type 1 N-terminal propeptide (PⅠNP), C-terminal-cross-linking telopeptide of type 1 collagen (β-CTX), 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH), and all of them completed the questionnaire. The associations between bone turnover markers and MS were analyzed using Spearman correlation and binary logistic regression, respectively. Results A total of 697 men with an age of (46.6±15.9) years were included in the study. The average body mass index (BMI) was (25.97±3.69) kg/m2 (17.1-39.0 kg/m2). After adjusted for age, PTH, 25(OH)D, BMI and smoke, BMI was found as a risk factor for MS (OR=1.263, 95%CI 1.198-1.332). Spearman correlation analysis showed that OC and PⅠNP was negatively associated with MS (r=-0.154, -0.107, both P<0.01), but there was no significant correlation between β-CTX and MS. The results of the binary logistic regression analysis showed that OC was a protective factor for MS, abdominal obesity, hyperglycemia, hypertension and high TG; after adjusted for age, PTH, 25(OH) D and BMI, osteocalcin was also a protective factor for hyperglycemia (OR=0.971, 95%CI 0.947-0.995) and high TG (OR=0.955, 95%CI 0.931-0.980); further adjusted for smoke, the results were same as before. PⅠNP was a protective factor for MS, abdominal obesity, hyperglycemia and hypertension; after adjusted for age, PTH and 25(OH)D, PⅠNP was also a protective factor for abdominal obesity (OR=0.993, 95%CI 0.988-0.999); further adjusted for BMI and smoke, there was no significant correlation between PⅠNP and abdominal obesity. Conclusion Weight control is important to prevent adult males from MS, and higher levels of osteocalcin and PⅠNP may help prevent MS. Key words: Osteocalcin; Pro-collagen type 1 N-terminal propeptide; C-terminal-cross-linking telopeptide of type 1 collagen; Metabolic syndrome; Males