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Abstract
Bone, vascular smooth muscle, and arachnoid trabeculae are composed of the same type of collagen. However, no studies have investigated the relationship between bone mineral density deterioration and cerebral atrophy, both of which occur in normal, healthy aging. Accordingly, we evaluated whether bone mineral density was associated with brain parenchymal atrophy and ventricular enlargement in healthy individuals. Intracranial cavity, brain parenchyma, and lateral ventricles volumes were measured using brain magnetic resonance imaging (MRI) with a semiautomated tool. We included 267 individuals with no history of dementia or other neurological diseases, who underwent one or more dual-energy X-ray absorptiometry scans and brain MRIs simultaneously (within 3 years of each other) at our hospital over an 11-year period. We found that progression of brain parenchymal atrophy was positively associated with bone mineral density after full adjustment (B, 0.94; P < 0.001). In addition, individuals with osteoporosis showed more parenchymal atrophy among those younger than 80 years. In addition, we observed greater ventricular enlargement in individuals with osteoporosis among those older than 80 years. We believe that osteoporosis may play a role in the acceleration of parenchymal atrophy during the early-stages, and ventricular enlargement in the late-stages, of normal aging-related cerebral atrophy.
Highlights
Cerebral atrophy and ventricular enlargement which occur during the normal aging process are known to lead to dementia, memory disorders, and cognitive impairment [1]
We found significant differences in ICV, brain parenchymal volume (BPV), lateral ventricles volume (LVV), and the intracranial cavity volume percentages of the brain parenchyma ((BPV/ ICV) × 100(%)) and lateral ventricles ((LVV/ICV) × 100(%)) between subjects with osteoporosis and those without
We found that the progression of brain parenchymal atrophy was positively associated with bone mineral density after adjusting for covariates, including age, in healthy individuals
Summary
Cerebral atrophy and ventricular enlargement which occur during the normal aging process are known to lead to dementia, memory disorders, and cognitive impairment [1]. To the best of our knowledge, there are no studies investigating the association between bone mineral density (BMD) and cerebral atrophy in healthy individuals. Vascular smooth muscle, and arachnoid trabeculae are composed of the same type of collagen, we hypothesized that osteoporosis may be linked to brain parenchymal atrophy and ventricular enlargement in the process of normal aging-related cerebral atrophy. We investigated this notion by analyzing T-scores from dual-energy X-ray absorptiometry (DXA) and measuring the intracranial cavity volume (ICV), brain parenchymal volume (BPV), and lateral ventricles volume (LVV) from brain magnetic www.aging-us.com resonance imaging (MRI) using a 3D slicer software in healthy individuals
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