Abstract
OBJECTIVESData on associations between body temperature (BT) and leukocyte telomere length (LTL), which has been widely used as a biomarker of cellular senescence in recent epidemiological studies, are limited. Therefore, this study aimed to explore the associations between a normal BT range (35.0-37.5°C) and LTL via 6-year longitudinal observations of 2,004 male and female adults aged 50 or older.METHODSBT was obtained by measuring the tympanic temperature, and relative LTL was determined by real-time polymerase chain reaction. Robust regression analysis was used to evaluate the association between the baseline and follow-up LTL values and their differences.RESULTSA significant inverse association was found between BT and LTL at baseline. The regression coefficient estimate was -0.03 (95% confidence interval, -0.07 to -0.001; p<0.05). This association was stronger in participants with a body mass index >25 kg/m2 and males (p<0.01). However, there were no associations between BT and LTL at follow-up or BT and 6-year longitudinal differences in LTL.CONCLUSIONSThese findings suggest that having a high BT between 35°C and 37.5°C (95°F and 99°F) may be detrimental for obese individuals in terms of biological aging.
Highlights
All living beings are able to experience birth, growth, reproduction, and death in accordance with the life cycle [1]
It has been estimated that up to 50% of biological variation is caused by genetic factors, of which telomere length has been found to be inversely associated with aging and can be used as a potential aging biomarker [3]
The mean body mass index (BMI) values tended to increase as body temperature (BT) increased (p < 0.01)
Summary
All living beings are able to experience birth, growth, reproduction, and death in accordance with the life cycle [1]. 2021, Korean Society of Epidemiology ological age (number of years lived) or biological age, which is one’s age relative to the estimated life span as determined by hereditary factors, the state of one’s health, and functioning capacity [2]. Specific aging biomarkers such as genetic indicators, molecular indicators, and environmental factors are used to estimate biological age. It has been estimated that up to 50% of biological variation is caused by genetic factors, of which telomere length has been found to be inversely associated with aging and can be used as a potential aging biomarker [3]. LTL has been found to be associated with lifestyle factors, chronic diseases, infections, and other
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