Abstract
BackgroundWe planned to determine the association of body mass index (BMI) with diabetes mellitus (DM) and impaired fasting glucose (IFG) in Chinese pulmonary tuberculosis (PTB) patients.Methods3,505 newly-diagnosed PTB patients registered in PTB clinics in Linyi of China between September 2010 and March 2013 were enrolled. DM and IFG were identified based on fasting plasma glucose levels. ROC analysis was used to predict the ability of screening of BMI for DM and IFG in PTB patients.ResultsCompared with 18.5–23.9 kg/m2, patients with DM and IFG had significantly increased trends when BMI ≥ 24.0 kg/m2, and aORs were 2.28 (95%CI 1.44–3.60) and 1.30 (95%CI 1.04–1.64), respectively. After adjustment for age, gender, and educational level, there was an increased odd in BMI ≥ 23.41 kg/m2 for IFG, and a decreased odd in BMI < 19.82 kg/m2 for DM (p < 0.05). The cut-offs of BMI for screening IFG and DM in PTB patients were 22.22 kg/m2 (AUC 0.56) and 22.34 kg/m2 (AUC 0.59).ConclusionsIn PTB patients, BMI is significantly associated with IFG and DM. However, the predictive power of BMI was not sufficient, so it may only be a limited screening tool for DM and IFG among PTB patients in China.
Highlights
We planned to determine the association of body mass index (BMI) with diabetes mellitus (DM) and impaired fasting glucose (IFG) in Chinese pulmonary tuberculosis (PTB) patients
The diagnosis of IFG was based on criteria for the classification of glucose tolerance based on the fasting plasma glucose (FPG) level, which was defined as a FPG range from 5.6–6.9 mmol/L (American Diabetes Association, 2014)
BMI means and the proportion of overweight or obese patients in the PTB + DM and PTB + IFG groups were higher than the PTB group (P < 0.05)
Summary
We planned to determine the association of body mass index (BMI) with diabetes mellitus (DM) and impaired fasting glucose (IFG) in Chinese pulmonary tuberculosis (PTB) patients. A number of studies have provided strong evidence of an association between patients who are overweight or obese and risk of DM [8,9,10]. A low BMI is a significant individual risk factor for development of recent active TB [11], and patients who are overweight have a decreased incidence of TB [12]. Studies involving the association between BMI and DM or IFG in PTB patients are limited [13], and no data are
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