Abstract
Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology.
Highlights
общий холестерин (ОХС), ТГ, ХС липопротеинов низкой плотности (ЛНП), ХС липопротеинов очень низкой плотности (ЛОНП), ХС липопротеинов высокой плотности (ЛВП), коэффициент атерогенности (КА), КТ, и >90 перцентилями глюкозы; между >90 перцентилями липидов крови: ОХС, ТГ, ХС ЛНП, ХС ЛОНП, ХС ЛВП, КА, КТ, и ≤10 перцентилями глюкозы
Сердечно-сосудистые заболевания (ССЗ), в т. ч. ишемическая болезнь сердца (ИБС) вносят наибольший (57%) вклад в смертность от неинфекционных заболеваний, при этом значительная доля случаев смерти от ишемической болезнью сердца (ИБС) приходится на трудоспособный возраст [1,2,3]
Информация о Международном Форуме кардиологов и терапевтов размещена на официальном сайте Форума www.cardioprogress.ru, а также на сайтах партнеров: www.roscardio.ru, www.rpcardio.ru, www. internist.ru, www.esculap-med.ru
Summary
Обследованы 82 мужчины (средний возраст – 50,5±0,9 года) с ИБС, ССН I–III функционального класса (ФК), МС и СД-2. Липидные параметры (ОХС, ТГ, ХС ЛНП, ХС ЛОНП, ХС ЛВП, КА, КТ) и глюкоза крови у мужчин с ИБС, ССН, МС и СД-2 представлены в таблице 2. Изучение параметров липидного спектра сыворотки крови и глюкозы капиллярной крови у мужчин с ИБС, МС и СД-2 показало, что у 66 (80%) пациентов (подгруппа “варианта”) значения ОХС, ХС ЛНП и ТГ превышали целевые показатели (p90 перцентиля”) отмечено статистически значимое (p
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
