Association between bladder fibrosis and oxidative stress in elderly diabetic patients

Abstract

Objective To investigate the association between bladder fibrosis and oxidative stress in elderly diabetic patients. Methods In this study, 30 elderly patients with bladder fibrosis related diabetes treated in our hospital from June 2017 to December 2017 were selected as the research object (observation group, n=30), and the healthy population (control group 1, n=30) and non bladder fibrotic senile diabetes mellitus (control group 2, n=30) in our hospital during the same period were used as control. Fasting blood glucose, postprandial 2H blood glucose and glycosylated hemoglobin were detected. Bladder dysfunction, urodynamic indexes and oxidative stress indexes were compared between the three groups. Multivariate logistic regression analysis was used to analyze the correlation between serum oxidative stress index and bladder fibrosis in elderly diabetic patients. Results The fasting blood glucose, postprandial blood glucose and glycosylated hemoglobin of control group 2 and observation group were higher than those of control group 1 (P 0.05). The incidence of unstable bladder, low compliance bladder and bladder depression in the observation group was higher than that in the control group 1 and the control group 2 (P<0.05). The maximal urine flow rate and detrusor contraction pressure in the observation group were lower than those in the control group 1 and the control group 2, and the residual urine volume was higher than that in the control group 1 and the control 2 group (P<0.05). The maximum bladder volume, initial urinary bladder capacity and average bladder capacity in the observation group were higher than those in the control group 1 and the control group 2 (P<0.05). The expression level of CAT and SOD in the observation group was lower than that of the control group 1 and the control 2 groups (P<0.05). The expression level of MDA was higher than that of the control group and the control group (P<0.05), and the expression level of CAT and SOD in the control group was lower than that of the control group (P<0.05), and the level of MDA expression was higher than that of the control group 2 (P<0.05). Multivariate logistic regression analysis showed that the expression levels of CAT, SOD and MDA were correlated with the incidence of bladder fibrosis related senile diabetes mellitus (P<0.05). Conclusions Bladder dysfunction in elderly patients with bladder fibrosis has some obstacles, abnormal urodynamic indexes and abnormal expression of oxidative stress indicators. Key words: Diabetes Mellitus; Aged; Urinary Bladder; Fibrosis; Oxidative Stress