Abstract
BackgroundAlthough prevalence of low birth weight has increased in the last 3 decades in Japan, no studies in Japanese women have investigated whether birth weight is associated with the risk of pregnancy complications, such as pregnancy-induced hypertension (PIH) and gestational diabetes mellitus (GDM).MethodsWe used data from the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT), a population-based cohort study in Japan that launched in 2011. In the main analysis, we included 46,365 women who had been pregnant at least once, for whom information on birth weight and events during their pregnancy was obtained using a self-administered questionnaire. Women were divided into five categories according to their birth weight, and the relationship between birth weight and risk of PIH and GDM was examined using multilevel logistic regression analyses with place of residence as a random effect.ResultsCompared to women born with birth weight of 3,000–3,999 grams, the risk of PIH was significantly higher among women born <1,500 grams (adjusted odd ratio [aOR] 1.60; 95% confidence interval [CI], 1.17–2.21), 1,500–2,499 grams (aOR 1.16; 95% CI, 1.03–1.30), and 2,500–2,999 grams (aOR 1.13; 95% CI, 1.04–1.22). The risk of GDM was significantly higher among women born 1,500–2,499 grams (aOR 1.20; 95% CI, 1.02–1.42), albeit non-significant association among women in other birthweight categories.ConclusionsWe observed an increased risk of PIH among women born with lower birth weight albeit non-significant increased risk of GDM among Japanese women.
Highlights
Studies show that the influence of being born with low birth weight has non-negligible influence on the individual
Birth Weight and Pregnancy Complications being born with lower birth weight and subsequent increased risk of preeclampsia[5,6,7,8] and gestational diabetes[9,10,11,12] during pregnancy
We targeted a population of Japanese women within the context of a large Japanese cohort study and examined the association between birth weight and risk of pregnancy complications, namely pregnancy-induced hypertension (PIH) and gestational diabetes (GDM)
Summary
Studies show that the influence of being born with low birth weight has non-negligible influence on the individual. Birth Weight and Pregnancy Complications being born with lower birth weight and subsequent increased risk of preeclampsia[5,6,7,8] and gestational diabetes[9,10,11,12] during pregnancy. We targeted a population of Japanese women within the context of a large Japanese cohort study and examined the association between birth weight and risk of pregnancy complications, namely pregnancy-induced hypertension (PIH) and gestational diabetes (GDM). Prevalence of low birth weight has increased in the last 3 decades in Japan, no studies in Japanese women have investigated whether birth weight is associated with the risk of pregnancy complications, such as pregnancyinduced hypertension (PIH) and gestational diabetes mellitus (GDM)
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