Abstract
OBJECTIVES:Previous studies have not shown any correlation between bile acid metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis. Thus, the current study evaluated the association between bile acid levels as well as BMD and bone turnover marker levels in this group of women.METHODS:This single-center cross-sectional study included 150 postmenopausal Chinese women. According to BMD, the participants were divided into three groups: osteoporosis group, osteopenia group, and healthy control group. Serum bile acid, fibroblast growth factor 19 (FGF19), and bone turnover biomarker levels were assessed. Moreover, the concentrations of parathyroid hormone, 25-hydroxy vitamin D [25(OH)D], procollagen type I N-peptide (P1NP), and beta-CrossLaps of type I collagen containing cross-linked C-terminal telopeptide (β-CTX) were evaluated. The BMD of the lumbar spine and proximal femur were examined via dual-energy X-ray absorptiometry.RESULTS:The serum total bile acid levels in the osteoporosis and osteopenia groups (5.28±1.56 and 5.31±1.56 umol/L, respectively) were significantly lower than that in the healthy control group (6.33±2.04 umol/L; p=0.002 and 0.018, respectively). Serum bile acid level was positively associated with the BMD of the lumbar spine, femoral neck, and total hip. However, it negatively correlated with β-CTX concentration. Moreover, no correlation was observed between bile acid and P1NP levels, and the levels of the other biomarkers that were measured did not differ between the groups.CONCLUSION:Serum bile acid was positively correlated with BMD and negatively correlated with bone turnover biomarkers reflecting bone absorption in postmenopausal women. Thus, bile acid may play an important role in bone metabolism.
Highlights
Osteoporosis is the most common bone disease, and it is characterized by low bone mass, destruction of bone microstructure, and increased bone fragility
General characteristics of the participants Altogether, 150 postmenopausal women aged over 50 years were included, and 52, 75, and 23 patients were classified under the osteoporosis, osteopenia, and control groups, respectively. 1 - Osteoporosis: Presence of fragility fractures in the absence of other metabolic bone disorders or a bone mineral density (BMD) T-score of -2.5 or lower in the lumbar spine, femoral neck or total hip measured by DXA; 2 - Osteopenia: -2.5oBMDT-scoreo-1.0 in the lumbar spine, femoral neck or total hip measured by DXA; 3 - control group: BMD T-scoreZ-1.0 in the lumbar spine, femoral neck or total hip measured by DXA
We evaluated the changes in serum bile acid and fibroblast growth factor 19 (FGF19) levels in Chinese women with postmenopausal osteoporosis, and the relationship between BMD and bile acid metabolism was assessed
Summary
Osteoporosis is the most common bone disease, and it is characterized by low bone mass, destruction of bone microstructure, and increased bone fragility. An epidemiological survey conducted in 2018 has shown that the prevalence of osteoporosis in the population aged over 50 years in China is 19.2%. The prevalence rate of osteoporosis in men was 6.0%, and that in women is as high as 32.1%. The prevalence rate of osteoporosis among women aged over 65 years is as high as 51.6%, and this rate is significantly. Received for publication on September 18, 2019. Accepted for publication on January 2, 2020
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