Association between bilateral postoperative neoangiogenesis in patients with moyamoya disease

Abstract

ObjectiveThe research on neoangiogenesis after indirect bypass for moyamoya disease (MMD) evaluated by using digital subtraction angiography (DSA) is limited. Our study objective was to investigate association of bilateral postoperative neoangiogenesis in patients with MMD. Patients and MethodsAll consecutive inpatients with MMD who received bilateral indirect bypass at Beijing Tiantan Hospital, Capital Medical University from January 2011 through December 2017 were screened. Bilateral neoangiogenesis was evaluated on lateral views and anteroposterior views by using DSA. ResultsTwenty-two patients (44 hemispheres) were included in this study. After a median 7.5 months DSA follow-up, on lateral views, 9 (40.9 %) hemispheres had grade A, 8 (36.4 %) hemispheres had grade B, and 5 (22.7 %) hemispheres had grade C after bypass on one side; 11 (50.0 %) hemispheres had grade A, 7 (31.8 %) hemispheres had grade B, and 4 (18.2 %) hemispheres had grade C after bypass on contralateral side. On anteroposterior views of ECA, 2 (9.1 %) hemispheres had level 0, 3 (13.6 %) had level 1, 6 (27.3 %) had level 2, and 11 (50.0 %) had level 3 after bypass on one side; 2 (9.1 %) hemispheres had level 0, 2 (9.1 %) had level 1, 6 (27.3 %) had level 2, and 12 (54.6 %) had level 3 after bypass on contralateral side. There was strong association between bilateral postoperative neoangiogenesis on lateral views (rs = 0.770; p = 0.000) and the anteroposterior views (rs = 0.548; p = 0.008). ConclusionsThere was strong association between bilateral postoperative neoangiogenesis. Postoperative neoangiogenesis on one side might predict the postoperative neoangiogenesis on the other side.