Association between baseline serum uric acid and development of LDL-C level in patients with first acute myocardial infarction

Yang Chen,Kai Zou,Renqiang Yang,Yanhui Liao,Yi Xia,Cong Dai,Yuanbin Zhao,Hanhui Liao,Longlong Hu,Yuehua Ruan,Congcong Ding

doi:10.1186/s12872-021-02383-x

Abstract

BackgroundData on the relationship of baseline serum uric acid (SUA) with development of low-density lipoprotein cholesterol (LDL-C) level in patients with first acute myocardial infarction (AMI) are limited. The present study is to evaluate whether elevated SUA predicts the development of LDL-C in the first AMI.MethodsThis is a retrospective 6-month cohort study of 475 hospitalized Chinese patients who underwent first AMI between January 2015 and December 2019 and were reevaluated half a year later at the Department of Cardiology, the Second Affiliated Hospital of Nanchang University, Jiangxi Province, China. The associations of baseline SUA with the percentage decrease of LDL-C (%) and LDL-C control were analyzed by using logistic regression analyses, multivariate linear regression analyses and the restricted cubic spline.ResultsOver the 6-month follow-up, baseline SUA was independently and positively associated with the percentage decrease of LDL-C (%) and LDL-C control in a dose response fashion. After multivariable adjustment, per SD increment of baseline SUA (120.58 μmol/L) was associated with 3.96% higher percentage decrease of LDL-C(%). The adjusted OR (95% CI) for LDL-C control was 5.62 (2.05, 15.36) when comparing the highest tertile (SUA ≥ 437.0 μmol/L) to the lowest tertile (< 341.7 μmol/L) of baseline SUA.ConclusionsAmong Chinese patients with first AMI, higher baseline SUA was associated with higher LDL-C deduction percentage (%), and higher rate of LDL-C control in the short-term follow-up, respectively. SUA acquired when AMI occurred was prone to be profitable in predicting the risk stratification of uncontrolled LDL-C and dyslipidemia management.

Highlights

Data on the relationship of baseline serum uric acid (SUA) with development of low-density lipoprotein cholesterol (LDL-C) level in patients with first acute myocardial infarction (AMI) are limited
Some cross-sectional studies have reported that hyperuricemia is primarily associated with hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C) and non-HDL-C[6,7,8,9,10]
Patients with high level of SUA tend to have a higher rate of males, smoke, use of diuretics, higher blood urea nitrogen (BUN), creatinine (CRE), estimated glomerular filtration rate during the admission and lower apolipoprotein A (ApoA), lower HDL-C, higher rate of LDL-C control after 6 months

Summary

Introduction

Data on the relationship of baseline serum uric acid (SUA) with development of low-density lipoprotein cholesterol (LDL-C) level in patients with first acute myocardial infarction (AMI) are limited. The present study is to evaluate whether elevated SUA predicts the development of LDL-C in the first AMI. High low-density lipoprotein cholesterol (LDL-C) is a strong risk factor for cardiovascular diseases[1]. A retrospective cohort study found that elevated SUA increases the risk for developing high LDL-C, as well as hypertriglyceridemia[11]. No studies investigated whether SUA predicts the change of LDL-C in patients with first acute myocardial infarction (AMI).

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Results

Conclusion