Abstract
AbstractEfferent auditory pathways modulate outer hair cells of the cochlea, protect against noise, and improve the detection of sound sources in noisy environments. Genotoxicity is DNA damage.Aim: To study the association between auditory pathway efferent functions with genotoxic markers. The study also considered smoking and gender as two main variables.Methods: A prospective-clinical, quantitative, cross-sectional, contemporary study. The function of efferent auditory pathways and genotoxicity tests in 60 healthy young subjects were assessed.Results: The mean age of subjects was 24.86 years +/- 3.68 years; there were 30 males and 30 females, 15 of each gender smokers and 15 non-smokers. Male smokers had a higher incidence of DPOEA suppression effect at 2000 and 6000 Hz in the left ear; female smokers had a higher prevalence of complaints of difficulty to hear in noisy environments; smokers and women had a higher mean DNA damage; subjects with complaints of hearing loss and tinnitus had higher genotoxicity.Conclusions: In young normal-hearing adults that complain about efferent auditory pathways functions, such as tinnitus and hearing impairment, there are possible associations with genotoxicity; interactions between gender and smoking are considered.
Highlights
The auditory system consists of afferent and efferent auditory pathways that operate in an integrated manner
Male smokers had a higher incidence of DPOEA suppression effect at 2000 and 6000 Hz in the left ear; female smokers had a higher prevalence of complaints of difficulty to hear in noisy environments; smokers and women had a higher mean deoxyribonucleic acid (DNA) damage; subjects with complaints of hearing loss and tinnitus had higher genotoxicity
In young normal-hearing adults that complain about efferent auditory pathways functions, such as tinnitus and hearing impairment, there are possible associations with genotoxicity; interactions between gender and smoking are considered
Summary
The auditory system consists of afferent and efferent auditory pathways that operate in an integrated manner. Efferent pathways consist of the medial and lateral olivocochlear bundles, which differ anatomically and physiologically to coordinate the independent function of both ears.[1]. The medial olivocochlear tract of the efferent system modulates the movements of the outer hair cells by releasing acetylcholine into the synaptic cleft.[4]. Efferent auditory pathways can be evaluated by applying a contralateral acoustic stimulus and simultaneously measuring otoacoustic emissions (OAEs). The OAE suppression effect by contralateral noise is used frequently in clinical and research settings because it assesses efferent pathways quickly and non-invasively
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.