Association between Arsenic and Generalized Anxiety Disorder: A Cross-Sectional Study

Na Wang,Li Wang,Linnan Guo,Lei Zhang,Minzhi Cao

doi:10.31579/2642-9756/054

Abstract

Aim: In some regionsof Bayannaoer arsenicconcentration in well drinking water is higherthan the international standard of 10 μg/L. The purpose of this study is to evaluate the impact of exposures to arsenic in drinking water on generalized anxiety disorder (GAD). Materials and Methods: Asurvey was conducted in2016 among villagers in Hangjinhou County,Bayannaoer City, Inner Mongolia. A questionnaire was used to inquire about GAD, arsenic related neurological symptoms. Arsenic concentration in the water was measured and arsenicosis prevalence was assessed. Multinomial logistic regression and ordinal logistic regression were performed to evaluate the association of abnormal arsenic levels on increased GAD symptoms. Results: 446 participants were enrolled. Subjectswith exposure to water arseniclevels>10 μg/L were significantly more likely to have mild GAD than controls (adjusted odds ratio [AOR] =2.3, 95% confidence interval [CI], 1.1-4.8). Participants who were diagnosed with arsenicosis were more likely to report mild anxiety than minimal anxiety compared to those who did not (AOR=2.3, 95% CI, 1.3-4.1). Survey respondents with palpitations, forgetfulness, headaches, dizziness, decreased taste, decreased hearing,loss of touch,abnormal warm and cold sensation, blurred vision, numbness and tingling were more likely to report mild, moderate and severe anxiety. Conclusions: Arsenic exposure was associated with a higher risk of GAD. Screening for arsenic exposure should be incorporated into the evaluation of GAD, in areas where arsenic in drinking water is known to be abnormal.

Highlights

Anxiety disorders are common psychiatric disorders among various people [1,2,3,4]
The purpose of this study is to evaluate the impact of exposures to arsenic in drinking water on generalized anxiety disorder (GAD)
Participants who were diagnosed with arsenicosis were more likely to report mild anxiety than minimal anxiety compared to those who did not (AOR=2.3, 95% CI, 1.3-4.1)

Summary

Introduction

Anxiety disorders are common psychiatric disorders among various people [1,2,3,4]. Generalized anxiety disorder (GAD) is the most common anxiety disorder [5]. People with GAD diagnostic often show excessive and persistent inexplicable tensions and fears with a lack of specific objects and specific content [6]. GAD has serious economic and social burdens in China. In the urban China, the prevalence of GAD was 5.3% [7]. Individuals with GAD are more likely to have suicidal ideation and attempt suicide than persons with other anxiety disorders [8, 9]

Objectives

Methods

Results

Conclusion