Abstract
BackgroundHyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association with different populations from different regions.ResultsA total of 59 articles were included, containing in total 13,843 hyperlipidemia patients in the case group and 15,398 healthy controls in the control group. Meta-analysis of the data indicated that APOA5–1131 T > C, APOA1 -75 bp, APOB XbaI, and APOE gene polymorphisms were significantly associated with hyperlipidemia, with OR values of 1.996, 1.228, 1.444, and 1.710, respectively. All P-values were less than 0.05.ConclusionsMeta-analysis of the data indicated that the C allele of APOA5 1131 T > C, the A allele at APOA1-75 bp, the APOB XbaI T allele, and the ε2 and ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia.
Highlights
Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease
Meta-analysis of the data indicated that the C allele of APOA5 1131 T > C, the A allele at APOA1-75 bp, the APOB XbaI T allele, and the ε2 and ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia
The APOB gene was investigated at three sites: MspI was studied in 6 case-control studies that included a hyperlipidemia group, with 1155 cases and 1043 controls; XbaI was studied in 12 case-control studies that included 1900 cases and 1836 controls; and EcorI was studied in 10 case-control studies that included 1633 cases and 1686 controls
Summary
Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Cardio-cerebrovascular disease is the leading cause of increased human mortality, globally [1]. Hyperlipidemia is a chronic non-communicable disease caused by an imbalance in the structure of plasma lipids caused by a fat metabolism disorder [3]. It is the primary risk factor for atherosclerosis and the pathological basis for cardio-cerebrovascular disease [4]. A large number of manuscripts have demonstrated that hyperlipidemia is a pathogenic factor of digestive and urinary diseases such as diabetes, hepatopathy, and pancreatitis.
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