Abstract
BackgroundApolipoprotein E (APOE) is involved in the pathogenesis of atherosclerosis and conveys a higher risk of coronary artery disease (CAD). The aim of the present study was to investigate the possible association between APOE gene polymorphism and the risk of CAD in postmenopausal Hakka women in southern China.MethodsThe APOE genotypes of 653 CAD patients and 646 control participants were determined by the polymerase chain reaction (PCR) and hybridization to a Sinochip.ResultsThe prevalence of each APOE genotype differed between CAD patients and control participants (P = 0.011). The E3/E3 genotype was the most common and the E2/E2 genotype was the least common in the study sample. Moreover, the presence of ε4 allele was associated with higher serum concentrations of triglycerides (TG), total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C), and lower concentration of high-density lipoprotein-cholesterol (HDL-C). Multiple logistic regression analysis revealed that participants with ε4 allele have a significantly higher risk of CAD after adjustment for the presence of diabetes mellitus and hypertension, and their serum uric acid, TC, and LDL-C concentrations (adjusted odds ratio (OR) 1.50, 95% confidence interval (CI) 1.10–2.05, P = 0.010).ConclusionsThe present results suggest that APOE polymorphism is associated with a higher risk of CAD in postmenopausal Hakka women in southern China.
Highlights
Apolipoprotein E (APOE) is involved in the pathogenesis of atherosclerosis and conveys a higher risk of coronary artery disease (CAD)
The study sample consisted of 1299 postmenopausal women
The CAD patients had significantly higher serum concentrations of Uric acid (UA), total cholesterol (TC), and low-density lipoprotein (LDL)-C than the control participants, but there were no significant differences in the TG and high-density lipoprotein-cholesterol (HDL-C) concentrations between the two groups
Summary
Apolipoprotein E (APOE) is involved in the pathogenesis of atherosclerosis and conveys a higher risk of coronary artery disease (CAD). The aim of the present study was to investigate the possible association between APOE gene polymorphism and the risk of CAD in postmenopausal Hakka women in southern China. Coronary artery disease (CAD) remains one of the most complex diseases with a high morbidity and mortality worldwide [1, 2]. It is well established that both genetic and environmental risk factors are involved in the development of CAD [3, 4]. Hypertension, diabetes mellitus, smoking, and poor diet have been shown to increase the risk of CAD [5, 6].
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