Abstract
BackgroundEpidemiological studies have evaluated the association between apolipoprotein E (ApoE) gene polymorphism and coronary artery disease (CAD) risk which developed inconsistent conclusions. To derive a more precise estimation of the relationship in Chinese population, we performed this meta-analysis.MethodsDatabases, including PubMed, EMbase, Web of Science, CBMdisc and CNKI, were searched to get the genetic association studies. Additionally, hand searching of the references of identified articles were performed. All the statistical tests were performed using Review Manager 5.1.2 and Stata 11.0.ResultsWe identified a total of 40 studies, including 4,564 CAD cases and 3,985 controls. The results showed evidence for significant association between ApoE ε4 allele and CAD risk (for ε2/ε4 vs. ε3/ε3: OR = 1.86, 95% CI = 1.42–2.43, p<0.00001; for ε3/ε4 vs. ε3/ε3: OR = 2.34, 95% CI = 2.07–2.65, p<0.00001; for ε4/ε4 vs. ε3/ε3: OR = 2.89, 95% CI = 1.87–4.47, p<0.00001; for ε4 allele vs. ε3 allele: OR = 2.11, 95% CI = 1.91–2.35, p<0.00001).ConclusionsThe present meta-analysis suggests an association between ApoE ε4 allele and increased risk of CAD in Chinese population. However, due to the small sample size in most of the included studies and the selection bias existed in some studies, the results should be interpreted with caution.
Highlights
Coronary artery disease (CAD) is the most common cardiovascular disease, and its incidence is increasing in the developing countries
Despite it is well established that a poor diet, advanced age, smoking, hypertension, diabetes, and dyslipidemia are associated with increased risk of coronary artery disease (CAD), a detailed etiology underlying CAD is still obscure
Numerous molecular epidemiological studies have focused on the association between apolipoprotein E (ApoE) gene polymorphism and CAD risk, and indicated that ApoE e4 allele exerts an important role in the development of CAD
Summary
Coronary artery disease (CAD) is the most common cardiovascular disease, and its incidence is increasing in the developing countries. Numerous molecular epidemiological studies have focused on the association between apolipoprotein E (ApoE) gene polymorphism and CAD risk, and indicated that ApoE e4 allele exerts an important role in the development of CAD. A variety of molecular epidemiological studies have focused on the relationship between ApoE gene polymorphism and CAD risk. A meta-analysis of worldwide studies including 48 studies has provided evidence that the e4 allele of ApoE was a risk factor for the development of CAD [7]. Considering that potential ethnic difference might be associated with the distribution of genotypes, we conducted a meta-analysis by collecting and sorting the previously published studies in Chinese population. Epidemiological studies have evaluated the association between apolipoprotein E (ApoE) gene polymorphism and coronary artery disease (CAD) risk which developed inconsistent conclusions. To derive a more precise estimation of the relationship in Chinese population, we performed this meta-analysis
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