Abstract
BackgroundThe central executive network (CEN), salience network (SN), and default mode network (DMN) are the three most studied depression-related brain networks. Many studies have shown that they are related to depression symptoms and treatment effects. However, few studies have related these three networks and their activity frequency bands to depressive symptoms and treatment efficacy.MethodsSixty-six medication-free patients with major depressive disorder (MDD) were enrolled. Magnetoencephalography (MEG) was administered at baseline to calculate imaging indicators such as the power and functional connectivity (FC) of each brain network. The Hamilton Rating Score for Depression (HRSD-17) was assessed at baseline and weekly for 4 weeks. Pearson correlation and receiver operating characteristic curves (ROC) analyses were used to explore the relationship between brain imaging indicators and antidepressant efficacy.ResultsThe difference between therapeutically effective and ineffective groups was mainly manifested in the beta power of the SN. The FC of beta waves between the three networks was related to antidepressant efficacy, with ROC analysis results of AUC = 0.794, P = 0.004, sensitivity = 76.7%, and specificity = 81.8%.LimitationsThe sample size was small and a healthy control group was not available.ConclusionsThe interaction between the three networks is related to antidepressant efficacy and the relief of depressive symptoms.
Highlights
The prevalence of depression is increasing year by year, and society is paying increasing attention to this important issue
The functional connectivity (FC) of beta waves between the three networks was related to antidepressant efficacy, with receiver operating characteristic curves (ROC) analysis results of AUC = 0.794, P = 0.004, sensitivity = 76.7%, and specificity = 81.8%
The central executive network (CEN), which is composed of the dorsolateral prefrontal cortex, anterior cingulate cortex, and parts of the parietal lobe [6], is a network closely related to the pathological mechanism of major depressive disorder (MDD)
Summary
The prevalence of depression is increasing year by year, and society is paying increasing attention to this important issue. The imaging of brain networks is an important method for research on efficacy of depression treatment. Three core brain networks are the most studied, namely the default mode network (DMN), central executive network (CEN), and salience network (SN) at baseline [2]. Each of these three networks plays a role in the onset, symptoms, and antidepressant efficacy of depression. The central executive network (CEN), salience network (SN), and default mode network (DMN) are the three most studied depression-related brain networks. Few studies have related these three networks and their activity frequency bands to depressive symptoms and treatment efficacy
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