Association between Angiopoietin-2 Gene Polymorphisms and Susceptibility to Coronary Artery Disease.

Luhang Lan,Liang Lu,Chen-Ming Su,Le Kang,Weimin Li,Hongping Si,Maofeng Wang,Jiren Peng,Xuan Ge

doi:10.34172/aim.2021.88

Abstract

Angiopoietin-2 (Angpt2) is associated with the progression of coronary artery disease (CAD). This research aimed to investigate the possible association between single nucleotide polymorphisms (SNPs) of ANGPT2 and CAD. This research was performed in a hospital from the eastern region of China. From February 2019 to June 2019, 222 patients with CAD were newly diagnosed and 403 healthy controls were confirmed by physical examinations. The distribution frequency of five SNPs of the ANGPT2 (rs11137037, rs2442598, rs12674822, rs1823375, and rs734701) in all participants was analyzed by real-time polymerase chain reaction (PCR) with SNP locus-specific probes. Our data showed that the participants with the TT genotype of rs2442598 were at reduced risk of CAD compared with wild-types (adjusted odds ratio [AOR] = 0.511, 95% CI: 0.283-0.923). The participants with the AC and AC+CC genotypes of rs11137037 were at greater risk of CAD compared to wild-types (AOR = 1.754, 95% CI: 1.140-2.699; AOR = 1.731, 95% CI: 1.165-2.573, respectively). In addition, carriers of the GG+TT genotypes of rs12674822, showed more significant high-density lipoprotein than those of GG genotype, in addition, carriers of the GG+TT genotypes of rs12674822, showed more significant high-density lipoprotein than those of GG genotype (P=0.037). These findings, as well as analysis of the haplotype, clearly indicate that ANGPT2 SNPs were highly correlated with susceptibility to CAD among the Han Chinese population.

Highlights

Coronary artery disease (CAD) is a common disorder in which coronary atherosclerosis leads to narrowing or occlusion of the coronary vascular lumen, resulting in myocardial ischemia, hypoxia, and even necrosis.[1,2] With the improvement of living standards, the high mortality and morbidity resulting from coronary artery disease (CAD) has attracted increased attention in China.[3]
In rs2442598, individuals bearing the TT genotype were less likely to have CAD compared to patients with the AA genotype
In rs11137037, patients bearing the AC genotype were by 1.754-folds more likely to suffer from CAD compared to patients bearing the AA genotype (AOR = 1.754; 95% confidence intervals (CIs) 1.140–2.699; P < 0.05) and patients bearing AC+CC were by 1.731-folds more likely compared to patients bearing AA (AOR = 1.731; 95% CI 1.165-2.573; P < 0.05)

Summary

Introduction

Coronary artery disease (CAD) is a common disorder in which coronary atherosclerosis leads to narrowing or occlusion of the coronary vascular lumen, resulting in myocardial ischemia, hypoxia, and even necrosis.[1,2] With the improvement of living standards, the high mortality and morbidity resulting from CAD has attracted increased attention in China.[3] CAD is related to blood lipids, hypertension, diabetes, lifestyle, obesity, and dietary habits, the genetic background is a strong independent risk factor.[4,5] The association between genetic variation and CAD has been demonstrated by numerous studies.[6] identifying genetic factors is crucial for CAD, which can help us predict the occurrence and development of the disease earlier. This research aimed to investigate the possible association between single nucleotide polymorphisms (SNPs) of ANGPT2 and CAD.

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Conclusion